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Developmental regulation of the expression of sodium currents in Xenopus primary neurons
(SOCIEDAD BIOLGIA CHILE, 2006)
The electrophysiological properties of neurons are determined by the expression of defined complements of ion channels. Nonetheless, the regulation mechanisms of the expression of neuronal ion channels are poorly understood, ...
A new class of neurotoxin from wasp venom slows inactivation of sodium current
(Blackwell Science, 2000-06-01)
The effects of alpha-pompilidotoxin (alpha-PMTX), a new neurotoxin isolated from the venom of a solitary wasp, were studied on the neuromuscular synapses in lobster walking leg and the rat trigeminal ganglion (TG) neurons. ...
Anestésicos locais: interação com membranas biológicas e com o canal de sódio voltagem-dependente
(Sociedade Brasileira de Química, 2014)
Interaction of local anesthetics with a peptide encompassing the IV/S4-S5 linker of the Na+ channel
(Elsevier Science BvAmsterdamHolanda, 2006)
Parabens inhibit hNaV 1.2 channels
(Elsevier Masson, 2020-08)
Propylparaben, a commonly used antimicrobial preservative, has been reported as an anticonvulsant agent targeting neuronal Na+ channels (NaV). However, the specific features of the NaV channel inhibition by this agent have ...
Gene variant effects across sodium channelopathies predict function and guide precision therapy
(2022)
Pathogenic variants in the voltage-gated sodium channel gene family lead to early onset epilepsies, neurodevelopmental disorders, skeletal muscle channelopathies, peripheral neuropathies and cardiac arrhythmias. ...
Barium, Tea and Sodium Sensitive Potassium Channels are Present in the Human Placental Syncytiotrophoblast Apical Membrane
(W B SAUNDERS CO LTD, 2008-10)
The human placental syncytiotrophoblast (hSTB) is a polarized epithelial structure, without paracellular
routes, forming the main barrier for materno–fetal exchange. There is ample evidence suggesting the
presence of ...
Axons provide the secretory machinery for trafficking of voltage-gated sodium channels in peripheral nerve
(National Academy of Sciences, 2016)
The regulation of the axonal proteome is key to generate and maintain neural function. Fast and slow axoplasmic waves have been known for decades, but alternative mechanisms to control the abundance of axonal proteins based ...
E Prostanoid-1 receptor regulates renal medullary aENaC in rats infused with angiotensin II
(Elsevier Inc., 2009)
E Prostanoid (EP) receptors play an important role in urinary Na+ excretion. In the kidney, the epithelial
sodium channel (ENaC) is the rate-limiting-step for Na+ reabsorption. We hypothesized that activation of
EP1/EP3 ...