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Protein Disulfide Isomerase Is Required for Platelet-derived Growth Factor-induced Vascular Smooth Muscle Cell Migration, Nox1 NADPH Oxidase Expression, and RhoGTPase Activation
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INCBETHESDA, 2012)
Vascular Smooth Muscle Cell (VSMC) migration into vessel neointima is a therapeutic target for atherosclerosis and postinjury restenosis. Nox1 NADPH oxidase-derived oxidants synergize with growth factors to support VSMC ...
GTPases of the Rho subfamily are required for Brucella abortus internalization in nonprofessional phagocytes
(The American Society for Biochemistry and Molecular Biology, Inc., 2001-11-30)
Members of the genus Brucella are intracellular -Proteobacteria
responsible for brucellosis, a chronic disease
of humans and animals. Little is known about Brucella
virulence mechanisms, but the abilities of these ...
Sonic Hedgehog Activates the GTPases Rac1 and RhoA in a Gli-Independent Manner Through Coupling of Smoothened to Gi Proteins
(American Association For The Advancement Of Science, 2011)
Pharmacological inhibition of Rac1-PAK1 axis restores tamoxifen sensitivity in human resistant breast cancer cells
(Elsevier Science Inc, 2017-01)
Tamoxifen is a standard endocrine therapy for estrogen receptor positive breast cancer patients. Despite its success,development of resistance mechanisms is still a serious clinical problem. Deregulation of survival ...
HIV-1 enhances mTORC1 activity and repositions lysosomes to the periphery by co-opting Rag GTPases
(Nature Publishing Group, 2017)
HIV-1 co-opts several host machinery to generate a permissive environment for viral replication and transmission. In this work we reveal how HIV-1 impacts the host translation and intracellular vesicular trafficking ...
Dynamin-2 regulates the late steps of exocytosis in adrenal chromaffin cells through a mechanism that involves actin polymerizatión
(2014)
Dynamin is a GTPase required for the vesicle pinching off from the plasma membrane during the late steps of endocytosis. Growing evidences suggest that dynamin also participates duringregulated exocytosis; however its ...
Dynamin-2 regulates the late steps of exocytosis in adrenal chromaffin cells through a mechanism that involves actin polymerizatión
(2014)
Dynamin is a GTPase required for the vesicle pinching off from the plasma membrane during the late steps of endocytosis. Growing evidences suggest that dynamin also participates duringregulated exocytosis; however its ...
Anti-glycan antibodies halt axon regeneration in a model of Guillain Barrè Syndrome axonal neuropathy by inducing microtubule disorganization via RhoA-ROCK-dependent inactivation of CRMP-2
(Academic Press Inc Elsevier Science, 2016-04)
Several reports have linked the presence of high titers of anti-Gg Abs with delayed recovery/poor prognosis in GBS. In most cases, failure to recover is associated with halted/deficient axon regeneration. Previous work ...
RAP1 GTPase Overexpression is Associated with Cervical Intraepithelial Neoplasia.
(Public Library of Science, 2016)
Rab24 interacts with the Rab7/Rab interacting lysosomal protein complex to regulate endosomal degradation
(Wiley Blackwell Publishing, Inc, 2016-11)
Endocytosis is a multistep process engaged in extracellular molecules internalization. Several proteins including the Rab GTPases family coordinate the endocytic pathway. The small GTPase Rab7 is present in late endosome ...