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Synthesis and total 1H- and 13C-NMR assignment of cephem derivatives for use in ADEPT approaches
(Molecular Diversity Preservation Int, 2014)
Development and clinical application of phosphorus-containing drugs
Phosphorus-containing drugs belong to an important class of therapeutic agents and are widely applied in daily clinical
practices. Structurally, the phosphorus-containing drugs can be classified into phosphotriesters, ...
The Role of the Phosphorus Atom in Drug Design
(Wiley VCH Verlag, 2019-01)
Although the phosphorus atom is found in a variety of oxidation states, most of the phosphorus-containing molecules of pharmacological importance possess phosphorus in the form of phosphonate or phosphinate functional ...
O processo de latenciação no planejamento de fármacos
(Sociedade Brasileira de Química, 1999-02-01)
Short review about the main aspects of prodrug design, as its objectives, applicability and importance, showing the new trends in the research for selective latent forms, namely targeted drugs.
Bifosfonatos (BFs) como transportadores osteotrópicos no planejamento de fármacos dirigidos
(Sociedade Brasileira de Química, 2004-06-01)
Drug therapy involving bone tissue diseases is difficult, calling for the design of specific drugs. The present paper is a brief review of a new site-directed system termed ODDS (osteotropic drug delivery system), based ...
Synthesis, ex Vivo and in Vitro Hydrolysis Study of an Indoline Derivative Designed as an Anti-Inflammatory with Reduced Gastric Ulceration Properties
(Molecular Diversity Preservation International-mdpi, 2009-09-01)
The compound 1-(2,6-dichlorophenyl)indolin-2-one (1), planned as a pro-drug of diclofenac (2), was easily synthesized in 94% yield by an intramolecular reaction in the presence of coupling agent (i.e., EDC). Compound 1 ...
Synthesis, ex Vivo and in Vitro Hydrolysis Study of an Indoline Derivative Designed as an Anti-Inflammatory with Reduced Gastric Ulceration Properties
(Molecular Diversity Preservation International-mdpi, 2009-09-01)
The compound 1-(2,6-dichlorophenyl)indolin-2-one (1), planned as a pro-drug of diclofenac (2), was easily synthesized in 94% yield by an intramolecular reaction in the presence of coupling agent (i.e., EDC). Compound 1 ...
O processo de latenciação no planejamento de fármacos
(Sociedade Brasileira de Química, 1999-02-01)
Short review about the main aspects of prodrug design, as its objectives, applicability and importance, showing the new trends in the research for selective latent forms, namely targeted drugs.
Bifosfonatos (BFs) como transportadores osteotrópicos no planejamento de fármacos dirigidos
(Sociedade Brasileira de Química, 2004-06-01)
Drug therapy involving bone tissue diseases is difficult, calling for the design of specific drugs. The present paper is a brief review of a new site-directed system termed ODDS (osteotropic drug delivery system), based ...
The latentiation process in drug design.
(Soc Brasileira Quimica, 1999-01-01)
Short review about the main aspects of prodrug design, as its objectives, applicability and importance, showing the new trends in the research for selective latent forms, namely targeted drugs.