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Involvement of PI3-kinase and its association with c-Src in PTH-stimulated rat enterocytes
(Wiley-liss, Div John Wiley & Sons Inc, 2002-06)
Phosphoinositide-3-kinase (PI3K) is a lipid kinase, which phosphorylates the D3 position of phosphoinositides, and is known to be activated by a host of protein tyrosine kinases. PI3K plays an important role in mitogenesis ...
Thyroid hormone stimulates NO production via activation of the PI3K/Akt pathway in vascular myocytes
(OXFORD UNIV PRESS, 2010)
Aims Thyroid hormone (TH) rapidly relaxes vascular smooth muscle cells (VSMCs). However, the mechanisms involved in this effect remain unclear. We hypothesize that TH-induced rapid vascular relaxation is mediated by ...
Protein kinase B (AKT) upregulation and Thy‑1‑αvβ3 integrin‑induced phosphorylation of Connexin43 by activated AKT in astrogliosis
(2023)
Background: In response to brain injury or inflammation, astrocytes undergo hypertrophy, proliferate, and migrate to the damaged zone. These changes, collectively known as "astrogliosis", initially protect the brain; ...
Efeito antitumoral de um inibidor de PLA2 de Crotalus durissus collilineatus (γCdcPLI) pela modulação da via PI3K/Akt em células de câncer de mama
(Universidade Federal de UberlândiaBrasilPrograma de Pós-graduação em Genética e Bioquímica, 2017)
Activation of the pi3k/akt signaling pathway by insulin-like growth factor type II stimulates the expression of marn metalloproteinase 9 in choriocarcinoma cellsLa activación de la vía de señalización pi3k/akt por el factor de crecimiento similar a la insulina tipo ii estimula la expresión del marn de la metaloproteinasa 9 en células de coriocarcinoma
(Revista Colombiana de Química, 2009)
Metalloproteinases 2 and 9 (MMP-2 and MMP-9) and MMP inhibitor-1 (TIMP-1) could contribute to the regulation of the invasive behavior of trophoblast cells, an effect that could be mediated by similar growth factor to insulin ...
PI3K/AKT pathway regulates phosphorylation of steroid receptors, hormone independence and tumor differentiation in breast cancer
(Oxford University Press, 2012-03)
Using a model of medroxyprogesterone acetate (MPA)-induced mouse mammary tumors that transit through different stages of hormone dependence, we previously reported that the activation of the phosphatidylinositol 3-kinase ...
AKT/GSK3β signaling pathway is critically involved in human pluripotent stem cell survival
(Nature Publishing Group, 2016-10)
Human embryonic and induced pluripotent stem cells are self-renewing pluripotent stem cells (PSC) that can differentiate into a wide range of specialized cells. Basic fibroblast growth factor is essential for PSC survival, ...