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La respuesta a proteínas mal plegadas como blanco terapéutico en la enfermedad de Alzheimer
(Sociedad Médica de Santiago, 2020)
The clinical features of Alzheimer's disease (AD), for example the progressive memory loss, are produced by neuronal loss and synaptic dysfunction. These events have been associated with histopathological alterations in ...
Behavioral and Neuropsychiatric Disorders in Alzheimer’s Disease
(IOS Press, 2018)
Alzheimer's disease (AD) is the most frequent type of dementia in the elderly, severely affecting functional and executive skills of subjects suffering from this disease. Moreover, the distress of caregivers as well as the ...
Tau Phosphorylation by cdk5 and Fyn in Response to Amyloid Peptide A beta(25-35): Involvement of Lipid Rafts
(IOS PRESS, 2009)
Alzheimer’s disease (AD) is characterized by the accumulation of protein filaments, namely extracellular amyloid-β
(Aβ) fibrils and intracellular neurofibrillary tangles, which are composed of aggregated hyperphosphorylated ...
Behavioral and Neuropsychiatric Disorders in Alzheimer’s Disease
(IOS Press, 2018)
Alzheimer's disease (AD) is the most frequent type of dementia in the elderly, severely affecting functional and executive skills of subjects suffering from this disease. Moreover, the distress of caregivers as well as the ...
Aggregation limiting cell-penetrating peptides derived from protein signal sequences
(MDPI, 2023-02-16)
Alzheimer’s disease (AD) is the most common neurodegenerative disease (ND) and the leading cause of dementia. It is characterized by non-linear, genetic-driven pathophysiological dynamics with high heterogeneity in the ...
Compensatory responses induced by oxidative stress in Alzheimer disease
(Sociedad de Biología de Chile, 2006)
Progressive supranuclear palsy: new concepts
(Academia Brasileira de Neurologia - ABNEURO, 2010-12-01)
Progressive supranuclear palsy (PSP) is a distinctive form of neurodegenerative disease which affects the brainstem and basal ganglia. Patients present supranuclear ophthalmoplegia, postural instability and mild dementia. ...
Increased platelet GSK3B activity in patients with mild cognitive impairment and Alzheimer`s disease
(PERGAMON-ELSEVIER SCIENCE LTD, 2011)
The disruption of glycogen synthase kinase 3-beta (GSK3B) homeostasis has implications in the pathophysiology of neuropsychiatric disorders, namely Alzheimer`s disease (AD). GSK3B activity is increased within the AD brain, ...