Buscar
Mostrando ítems 61-70 de 403
Palmitic and Stearic Acids Inhibit Chaperone-Mediated Autophagy (CMA) in POMC-like Neurons In Vitro
(2022-03-01)
The intake of food with high levels of saturated fatty acids (SatFAs) is associated with the development of obesity and insulin resistance. SatFAs, such as palmitic (PA) and stearic (SA) acids, have been shown to accumulate ...
ERK3 associates with MAP2 and is involved in glucose-induced insulin secretion
(Elsevier Ireland LtdClareIrlanda, 2006)
The Role of Physical Exercise to Improve the Browning of White Adipose Tissue via POMC Neurons
(Frontiers Media Sa, 2018-03-28)
Obesity is a public health issue that affects more than 600 million adults worldwide. The disease is characterized by fat accumulation, mainly in the abdominal area. The human body is mainly composed of two types of adipose ...
Glucose-Dependent Insulin Secretion in Pancreatic beta-Cell Islets from Male Rats Requires Ca2+ Release via ROS-Stimulated Ryanodine Receptors
(Public Library Science, 2015)
Glucose-stimulated insulin secretion (GSIS) from pancreatic beta-cells requires an increase in intracellular free Ca2+ concentration ([Ca2+]). Glucose uptake into beta-cells promotes Ca2+ influx and reactive oxygen species ...
The Phosphatase CSW Controls Life Span by Insulin Signaling and Metabolism Throughout Adult Life in Drosophila
(Frontiers Media S.A., 2020-05)
Noonan syndrome and related disorders are caused by mutations in genes encoding for proteins of the RAS-ERK1/2 signaling pathway, which affect development by enhanced ERK1/2 activity. However, the mutations’ effects ...
Long-term effects of intracerebroventricular insulin microinjection on renal sodium handling and arterial blood pressure in rats
(Pergamon-elsevier Science LtdOxfordInglaterra, 2008)
Regulation of glucose metabolism in neurons by adiponectin and resistin, a possible molecular link between brain dysfunction and obesity
(2018)
The brain is an organ with a high rate of glucose consumption and in several disorders, it has
been described a decrease in the brain capacity to utilize glucose including in Alzheimer´s
disease (AD) and obesity. Despite ...
Diapause induces functional axonal regeneration after necrotic insult in C. elegans
(PUBLIC LIBRARY SCIENCE, 2019)
Many neurons are unable to regenerate after damage. The ability to regenerate after an insult depends on life stage, neuronal subtype, intrinsic and extrinsic factors. C. elegans is a powerful model to test the genetic and ...