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Mitochondrial diabetes and deafness: Possible dysfunction of strial marginal cells of the inner ear
(2011)
Objective: Some patients with the syndrome of mitochondrial diabetes and deafness (MIDD) have a m.3243A>G mutation of the MTTL1 gene encoding transfer ribonucleic acid for the amino acid leucine (tRNALeu(UUR)). One of our ...
Mitochondrial Supercomplexes: Physiological Organization and Dysregulation in Age-Related Neurodegenerative Disorders
(Frontiers Media S.A., 2020-09)
Several studies suggest that the assembly of mitochondrial respiratory complexes into structures known as supercomplexes (SCs) may increase the efficiency of the electron transport chain, reducing the rate of production ...
Heart mitochondrial dysfunction in diabetic rats
(Sociedad Latinoamericana de Microscopía Electrónica; Centro Regional de Investigaciones Científicas y Tecnológicas, 2016-04)
Diabetic cardiomyopathy, i.e. the ventricular dysfunction in the absence of hypertension or coronary arterial disease, is a common complication of diabetes mellitus that leads to a heightened risk of heart failure and death ...
Mitochondrial Bioenergetics Is Altered in Fibroblasts from Patients with Sporadic Alzheimer's Disease
(2017)
The identification of an early biomarker to diagnose Alzheimer's disease (AD) remains a challenge. Neuropathological studies in animal and AD patients have shown that mitochondrial dysfunction is a hallmark of the development ...
Mitochondrial permeability transition pore as a suitable target for neuroprotective agents against alzheimer’s disease
(Bentham Science Publishers B.V., 2017)
Effect of cholic bile acid and deoxycholic acid through TGR5 receptor on skeletal muscle atrophy and mitochondrial dysfunction in the skeletal muscle.
(2020)
The skeletal muscle atrophy consists in muscle mass loss and decreased force generation, produced by molecular mechanisms such as oxidative stress and imbalance in synthesis/degradation proteins processes, that generates ...
Mitochondrial genome instability in colorectal adenoma and adenocarcinoma
(2015-11-01)
Mitochondrial dysfunction is regarded as a hallmark of cancer progression. In the current study, we evaluated mitochondrial genome instability and copy number in colorectal cancer using Next Generation Sequencing approach ...
Endoplasmic reticulum-mitochondria coupling increases during doxycycline-induced mitochondrial stress in HeLa cells
(SpringerNature, 2021)
Subcellular organelles communicate with each other to regulate function and coordinate responses to changing cellular conditions. The physical-functional coupling of the endoplasmic reticulum (ER) with mitochondria allows ...