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Avaliação do impacto de mutações na região C-terminal da proteína rLID1, uma esfingomielinase do veneno da aranha Loxosceles intermedia, em sua atividade enzimática
(Universidade Federal de Minas GeraisUFMG, 2017-05-29)
In Brazil, during the year 2015 (last available data), there were 106,983 cases of accidents with venomous animals. Of this total, 19,495 involved spiders (18.22%). The state of Minas Gerais had the highest number of ...
Oligosaccharide residues of Loxosceles intermedia (brown spider) venom proteins: dependence on glycosylation for dermonecrotic activity
(Elsevier B.V., 1999-04-01)
Loxosceles spp. (brown spider) envenomation has been reported to provoke dermonecrosis and haemorrhage at the bite site (a hallmark of accidents) and, to a lesser extent, thrombocytopenia, hemolysis and disseminated ...
Aspecto fisiopatológicos e imunológicos induzidos pelo veneno e pela proteína dermonecrótica recombinante (rLiDi) da aranha marrom Loxosceles intermedia em coelhos
(Universidade Federal de Minas GeraisUFMG, 2009-03-13)
In this work we shown the local and systemic disorders induced administration of the whole venom of L. intermedia and the recombinant protein dermonecrótica (rLiD1) in rabbits and the neutralization of these disorders by ...
Active site mapping of Loxosceles phospholipases D: Biochemical and biological features
(Elsevier Science Bv, 2016)
Brown spider phospholipases D from Loxosceles venoms are among the most widely studied toxins since they induce dermonecrosis, triggering inflammatory responses, increase vascular permeability, cause hemolysis, and renal ...
Active site mapping of Loxosceles phospholipases D: Biochemical and biological features
(2016-09-01)
Brown spider phospholipases D from Loxosceles venoms are among the most widely studied toxins since they induce dermonecrosis, triggering inflammatory responses, increase vascular permeability, cause hemolysis, and renal ...
Efeitos de metaloproteases do veneno de jararaca (Bothrops leucurus) e do veneno de aranha marrom (Loxosceles intermedia) sobre células endoteliais e componentes da matriz extracelular
(Universidade Federal de São Paulo (UNIFESP), 2006)
A nova metaloprotease fibrinolítica isolada do veneno de Bothrops leucurus, denominada leucurolisina-a (23kDa), apresenta-se como um componente de significativo potencial terapêutica para o tratamento de distúrbios de ...