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Proteção parical à infecção por L. amazonensis na infecção concomitante com L. major
(Universidade Federal de Minas GeraisUFMG, 2008-02-22)
Experimental murine infections with Leishmania spp. that cause cutaneous leishmaniasis has led to an understanding of many immunological events that are required for a successful host response towards these protozoan ...
ST2 regulates bone loss in a site-dependent and estrogen-dependent manner
(Wiley-Blackwell, 2018-11-01)
Interleukin-33 (IL-33) and its receptor, ST2, are implicated in bone remodeling. The lack of estrogen after menopause results in an accelerated bone loss. Here we investigated the role of ST2 in the bone loss induced by ...
Wiskott Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development
(National Academy of Sciences, 2020)
TLR2 Is a Negative Regulator of Th17 Cells and Tissue Pathology in a Pulmonary Model of Fungal Infection
(AMER ASSOC IMMUNOLOGISTS, 2009)
To study the role of TLR2 in a experimental model of chronic pulmonary infection, TLR2-deficient and wild-type mice were intratracheally infected with Paracoccidioides brasiliensis, a primary fungal pathogen. Compared with ...
Lack of TNFR p55 results in heightened expression of ifn-γ and IL-17 during the development of reactive arthritis
(American Association of Immunologists, 2010-10)
Reactive arthritis (ReA) is a type of arthritis originating from certain gastrointestinal or genitourinary infections. In previous studies, we reported the development of progressive Yersinia enterocolitica-induced ReA in ...
Unconventional pro-inflammatory CD4+ T cell response in B cell-deficient mice infected with Trypanosoma cruzi
(Frontiers Research Foundation, 2017-11-21)
Chagas disease, caused by the parasite Trypanosoma cruzi, is endemic in Latin America but has become a global public health concern by migration of infected people. It has been reported that parasite persistence as well ...
Alveolar macrophages from susceptible mice are more competent than those of resistant mice to control initial Paracoccidioides brasiliensis infection
(FEDERATION AMER SOC EXP BIOL, 2008)
Alveolar macrophages ( AM) are the first host cells to interact with Paracoccidioides brasiliensis (Pb), a primary human pathogen that causes severe pulmonary infections in Latin America. To better understand innate immunity ...
Deficiency in the incorporation of labeled thymidine and inhibition in the biosynthesis of interleukin-2 in lymphocytes obtained from Histoplasma capsulatum infected mice
(1991)
The incorporation of (3H) thymidine and the biosynthesis of interleukin-2(IL-2) were investigated in Concanavalin A (ConA) and histoplasmin stimulated lymphocytes from spleen of infected Balb/c mice with the yeast phases ...
Decay-Accelerating Factor 1 Deficiency Exacerbates Leptospiral-Induced Murine Chronic Nephritis and Renal Fibrosis
(Public Library of Science, 2014-07)
Leptospirosis is a global zoonosis caused by pathogenicLeptospira, which can colonize the proximal renal tubules andpersist for long periods in the kidneys of infected hosts. Here, we characterized the infection of C57BL/6J ...
TLR4 deficiency upregulates TLR9 expression and enhances irinotecan-related intestinal mucositis and late-onset diarrhoea
(2021-10-01)
Background and purpose: Severe diarrhoea, a common gastrointestinal manifestation of anticancer treatment with irinotecan, might involve single nucleotide polymorphisms (SNPs) of toll-like receptors (TLRs), described as ...