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IEDB-AR: immune epitope database - analysis resource in 2019
(Oxford University Press, 2019-07-02)
The Immune Epitope Database Analysis Resource (IEDB-AR, http://tools.iedb.org/) is a companion website to the IEDB that provides computational tools focused on the prediction and analysis of B and T cell epitopes. All of ...
T-cell recognition is shaped by epitope sequence conservation in the host proteome and microbiome
(Wiley Blackwell Publishing, Inc, 2016-05)
Several mechanisms exist to avoid or suppress inflammatory T-cell immune responses that could prove harmful to the host due to targeting self-antigens or commensal microbes. We hypothesized that these mechanisms could ...
Identification and evaluation of universal epitopes in Plasmodium vivax Duffy binding protein
Selected PvDBP-derived synthetic peptides were tested in competition assays with HLA molecules in order to identify and evaluate their binding to a wide range of MHC class II molecules. Binding was evaluated as the peptide's ...
Impact of glycan cloud on the B-cell epitope prediction of SARS-CoV-2 Spike protein
The SARS-CoV-2 outbreak originated in China in late 2019 and has since spread to pandemic proportions. Diagnostics, therapeutics
and vaccines are urgently needed. We model the trimeric Spike protein, including flexible ...
A Proteome-Wide Immunoinformatics Tool to Accelerate T-Cell Epitope Discovery and Vaccine Design in the Context of Emerging Infectious Diseases : An Ethnicity-Oriented Approach
(2021-02-26)
Emerging infectious diseases (EIDs) caused by viruses are increasing in frequency, causing a high disease burden and mortality world-wide. The COVID-19 pandemic caused by the novel SARS-like coronavirus (SARS-CoV-2) ...
Use of “one-pot, mix-and-read” peptide-MHC class I tetramers and predictive algorithms to improve detection of cytotoxic T lymphocyte responses in cattle
(BioMed Central, 2014-04)
Peptide-major histocompatibility complex (p-MHC) class I tetramer complexes have facilitated the early detection and functional characterisation of epitope specific CD8+ cytotoxic T lymphocytes (CTL). Here, we report on ...
Dynamic identification of H2 epitopes from Leishmania (Leishmania) amazonensis cysteine proteinase B with potential immune activity during murine infection
(John Wiley and SonsWest Sussex, 2014-02)
Peptides from the COOH-terminal extension of cysteine proteinase B from Leishmania (Leishmania) amazonensis (cyspep) can modulate immune responses in vertebrate hosts. With this hypothesis as base, we used the online ...
Improved methods for predicting peptide binding affinity to MHC class II molecules
(Wiley Blackwell Publishing, Inc, 2018-07)
Major histocompatibility complex class II (MHC-II) molecules are expressed on the surface of professional antigen-presenting cells where they display peptides to T helper cells, which orchestrate the onset and outcome of ...
Multi-epitope based vaccine against yellow fever virus applying immunoinformatics approaches
(Taylor & Francis, 2020)