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The role of short-chain fatty acids from gut microbiota in gut-brain communication
(Frontiers Media, 2020)
Transcriptomics of the late gestation ovine fetal brain: modeling the co-expression of immune marker genes
(BioMed Central, 2014-11)
Background: Major changes in gene expression occur in the fetal brain to modulate the function of this organ postnatally. Thus, factors can alter the genomics of the fetal brain, predisposing to neurological disorders later ...
Expression of key steroidogenic enzymes in developing brain: hormonal compensation of sex chromosomes-induced sex differences
(2014)
Developing brain of mammals is organized by gonadal steroids during the critical period of sexual differentiation (E18-PN10). The regulatory role of neurosteroids in the early brain is unclear. It is known that 17-β-estradiol ...
The serine protease homolog, scarface, is sensitive to nutrient availability and modulates the development of the drosophila blood brain barrier
(Soc. Neuroscience, 2021)
The adaptable transcriptional response to changes in food availability not only ensures animal survival but also lets embryonic development progress. Interestingly, the CNS is preferentially protected from periods of ...
Treating Metastatic Brain Cancers With Stem Cells
(Frontiers Media S.A., 2021-11-24)
Stem cell therapy may present an effective treatment for metastatic brain cancer and glioblastoma. Here we posit the critical role of a leaky blood-brain barrier (BBB) as a key element for the development of brain metastases, ...
Current state and future perspectives in QSAR models to predict blood-brain barrier penetration in central nervous system drug R&D
(Bentham Science Publishers, 2017-02)
The Blood-Brain Barrier (BBB) is a physical and biochemical barrier that restricts the entry of certain drugs to the Central Nervous System (CNS), while allowing the passage of others. The ability to predict the permeability ...
Gross brain morphology of the armoured catfish Rineloricaria heteroptera, Isbrücker and Nijssen (1976), (Siluriformes: Loricariidae: Loricariinae): A descriptive and quantitative approach
(2017-12-01)
The gross morphology of the brain of Rineloricaria heteroptera and its relation to the sensory/behavioural ecology of the species is described and discussed. The sexual and ontogenetic intraspecific variation in the whole ...