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Chlorhexidine induces DNA damage in rat peripheral leukocytes and oral mucosal cells
(Blackwell Munksgaard, 2004-10-01)
Objective: Chlorhexidine digluconate is widely used in dental practice for decreasing plaque control, controlling gingivitis and disinfecting root canals. However, the undesirable effects of chlorhexidine digluconate ...
Effect of Naringin on the DNA Damage Induced by Daunorubicin in Mouse Hepatocytes and Cardiocytes
(2010)
Naringin (Nar) is a flavonoid that has shown antigenotoxic effect against the chromosome damage inducedby various compounds. The aims of the present investigation on Nar were threefold: a) to determine its DNAbreaking ...
The G2 checkpoint activated by DNA damage does not prevent genome instability in plant cells
(2006)
Root growth, G2 length, and the frequency of aberrant mitoses and apoptotic nuclei were recorded after a
single X-ray irradiation, ranging from 2.5 to 40 Gy, in Allium cepa L. root meristematic cells. After 72 h of
recovery, ...
Melatonin prevents damage elicited by the organophosphorous pesticide diazinon on mouse sperm DNA
(2009)
Toxic effects of pesticides are commonly associated with DNA damage. To evaluate the effect of the organophosphate diazinon on sperm DNA and to test whether melatonin could prevent this damage, male mice were intraperitoneally ...
Bleomycin induces delayed instability of interstitial telomeric sequences in Chinese hamster ovary cells
(Elsevier Science, 2012-03)
We analyzed the behavior of interstitial telomeric sequences (ITSs) in the progeny of Chinese Hamster Ovary (CHO) cells exposed to the radiomimetic compound bleomycin (BLM) in order to determine if ITSs play some role in ...
Genotoxic effects of mercury chloride on the Neotropical fish Andinoacara rivulatus (Cichlidae: Cichlasomatini)
(Revista De Biologia Tropical, 2019-09-01)
Understanding the effects of heavy metals in aquatic ecosystems is of significant importance due to their potential to bioaccumulate at various trophic levels and induce damage in DNA. Mercury is considered one of the most ...
Genotoxic effects of mercury chloride on the neotropical fish andinoacara rivulatus (Cichlidae: Cichlasomatini)Efectos genotóxicos del cloruro de mercurio en el pez neotropical andinoacara rivulatus (Cichlidae: cichlasomatini).
(2019-09-01)
Understanding the effects of heavy metals in aquatic ecosystems is of significant importance due to their potential to bioaccumulate at various trophic levels and induce damage in DNA. Mercury is considered one of the most ...
An evaluation, using the comet assay and the micronucleus test, of the antigenotoxic effects of chlorophyll b in mice
(ELSEVIER SCIENCE BV, 2011)
We investigated the effects of the dietary pigment chlorophyll b (CLb) on cisplatin (cDDP)-induced oxidative stress and DNA damage, using the comet assay in mouse peripheral blood cells and the micronucleus (MN) test in ...
Instabilidade genômica resultante de alterações teloméricas e centroméricas define a evolução cariotípica do melanoma em um modelo murino
(Universidade Federal de São Paulo (UNIFESP), 2009)
Aneuploidia e instabilidade cromossômica são características da maioria
dos tumores sólidos. Estas alterações podem resultar da segregação
inapropriada dos cromossomos durante a divisões celulares, que pode ocorrer
por ...
Investigação da reorganização da cromatina em translocações X-autossomo equilibradas e sua influência no fenótipo
(Universidade Federal de São Paulo (UNIFESP), 2020-10-30)
This study aimed to study the effect of position as the main hypothesis to explain the genetic mechanism responsible for gonadal dysgenesis in these women. The investigation of the profile of gene expression and regulation ...