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TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family proteins through the LC3-interacting region (LIR) and promotes autophagy-dependent cell death
(Nature Publishing Group, 2012-09)
TP53INP1 (tumor protein 53-induced nuclear protein 1) is a tumor suppressor, whose expression is downregulated in cancers from different organs. It was described as a p53 target gene involved in cell death, cell-cycle ...
Simvastatin induces apoptosis by a Rho-dependent mechanism in cultured cardiac fibroblasts and myofibroblasts
(2011)
Several clinical trials have shown the beneficial effects of statins in the prevention of coronary heart disease. Additionally, statins promote apoptosis in vascular smooth muscle cells, in renal tubular epithelial cells ...
Autophagy protects against aminochrome-induced cell death in substantia nigra-derived cell line
(2011)
Aminochrome, the precursor of neuromelanin, has been proposed to be involved in the neurodegeneration neuromelanincontaining dopaminergic neurons in Parkinson's disease. We aimed to study the mechanism of aminochrome-dependent ...
Apoptosis neuronal : la diversidad de señales y de tipos celulares.
(2012-04-23)
La muerte celular programada es un evento fisiológico durante el desarrollo. En el encéfalo y la médula espinal, este proceso
determina el número y la localización de los diferentes tipos celulares. En el sistema nervioso ...
Antagonic activities of Trypanosoma cruzi metacaspases affect the balance between cell proliferation, death and differentiation
(Nature Publishing Group, 2012-08)
Metacaspases are distant relatives of animal caspases present in plants, fungi and protozoa. At variance with caspases, metacaspases exhibit stringent specificity for basic amino-acid residues and are absolutely dependent ...
Sustained Energy Deficit Following Perinatal Asphyxia: A Shift towards the Fructose-2,6-bisphosphatase (TIGAR)-Dependent Pentose Phosphate Pathway and Postnatal Development
(2022)
Labor and delivery entail a complex and sequential metabolic and physiologic cascade, culminating in most circumstances in successful childbirth, although delivery can be a risky episode if oxygen supply is interrupted, ...
Antitumor activity of irradiated riboflavin on human renal carcinoma cell line 786-O
(Springer, 2015-02-01)
Riboflavin (vitamin B-2) is a precursor for coenzymes involved in energy production, biosynthesis, detoxification, and electron scavenging. Previously, we demonstrated that irradiated riboflavin (IR) has potential antitumoral ...
Lutzomyia longipalpis saliva drives apoptosis and enhances parasite burden in neutrophils
(2011)
Neutrophils are considered the host's first line of defense against infections and have been implicated in the immunopathogenesis of Leishmaniasis. Leishmania parasites are inoculated alongside vectors' saliva, which is a ...