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Fibrosis-associated hepatocarcinogenesis revisited: Establishing standard medium-term chemically-induced male and female models
(2018-09-01)
Hepatocellular carcinoma causes ~10% of all cancer-related deaths worldwide, usually emerging in a background of liver fibrosis/cirrhosis (70%-90% of cases). Chemically-induced mouse models for fibrosis-associated ...
Heterozygous mutations of the voltage-gated sodium channel SCN8A are associated with spike-wave discharges and absence epilepsy in mice
(Oxford Univ Press, 2009-05-01)
In a chemical mutagenesis screen, we identified the novel Scn8a(8J) allele of the gene encoding the neuronal voltage-gated sodium channel Na(v)1.6. the missense mutation V929F in this allele alters an evolutionarily conserved ...
Impairment Of Toll-like Receptors 2 And 4 Leads To Compensatory Mechanisms After Sciatic Nerve Axotomy
(Biomed Central LtdLondon, 2016)
Synthetic peptides from two Pf sporozoite invasion-associated proteins specifically interact with HeLa and HepG2 cells
Two recently described molecules have been associated with sporozoite traversal ability and hepatocyte entry: sporozoite invasion-associated proteins (SIAP)-1 and -2. The HeLa and HepG2 cell binding ability of synthetic ...
Superior cervical gangliectomy induces non-exudative age-related macular degeneration in mice
(Company of Biologists, 2018)
Abstract: Non-exudative age-related macular degeneration, a prevalent cause of blindness, is a progressive and degenerative disease characterized by alterations in Bruch's membrane, retinal pigment epithelium, and ...
Impairment Of Toll-like Receptors 2 And 4 Leads To Compensatory Mechanisms After Sciatic Nerve Axotomy
(BIOMED CENTRAL LTDLONDON, 2016)