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What are the roles of antibodies versus a durable, high quality T-cell response in protective immunity against SARS-CoV2?
The first SARS-CoV2 vaccine(s) will likely be licensed based on neutralizing antibodies in Phase 2
trials, but there are significant concerns about using antibody response in coronavirus
infections as a sole metric of ...
Immune-boosting role of vitamins D, C, E, zinc, selenium and omega-3 fatty acids: could they help against COVID-19?
The world is currently in the grips of the coronavirus disease (COVID-19) pandemic, caused
by the SARS-CoV-2 virus, which has mutated to allow human-to-human spread. Infection can
cause fever, dry cough, fatigue, severe ...
IL-12 DNA Displays Efficient Adjuvant Effects Improving Immunogenicity of Ag85A in DNA Prime/MVA Boost Immunizations
(Frontiers Media, 2020-09)
Mycobacterium tuberculosis (Mtb) infection is one of the leading causes of death worldwide. The Modified Vaccinia Ankara (MVA) vaccine vector expressing the mycobacterial antigen 85A (MVA85A) was demonstrated to be safe, ...
Testing the efficacy of a multi-component DNA-prime/DNA-boost vaccine against Trypanosoma cruzi infection in dogs.
(2011)
Trypanosoma cruzi, the etiologic agent of Chagas Disease, is a major vector borne health problem in Latin America and an emerging infectious disease in the United States. We tested the efficacy of a multi-component ...
Influence of antibodies transferred by colostrum in the immune responses of calves to current foot-and-mouth disease vaccines
(Elsevier, 2014-11)
Immunity to currently used oil-adjuvanted inactivated vaccines against foot-and-mouth disease virus (FMDV) has been studied in detail in adult animals; however, the influence of maternally derived antibodies transferred ...
Desenvolvimento de vacinas recombinantes contra malária humana e teste in vivo em modelo murino
(Universidade Federal de Minas GeraisUFMG, 2009-05-22)
Vaccines that provide protection against malaria are urgently needed fordisease control. Several studies have demonstrated that Apical membrane antigen-1 (AMA-1) and 19KDa fragment of merozoit surface protein (MSP-119) are ...