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Development and therapeutic potential of vasopressin synthetic analog [V4Q5]dDAVP as a novel anticancer agent
(Elsevier Academic Press Inc., 2020-01)
Since its discovery, arginine vasopressin (AVP) was subjected to several modifications with the aim of obtaining novel derivatives with increased potency and selectivity for biomedical use. Desmopressin (dDAVP) is a first ...
Partial purification of peptides present in the Tityus macrochirus (Buthidae) scorpion venom and preliminary assessment of their cytotoxicity
(2017)
NTRODUCTION: Scorpion venom contains peptides with neurotoxic action primarily active on ion channels in the nervous system of insects and mammals. They are also characterized as cytolytic and anticancer, biological ...
CIGB-300, an anti-CK2 peptide, inhibits angiogenesis, tumor cell invasion and metastasis in lung cancer models
(Elsevier Ireland, 2017-05)
Objectives: Casein kinase 2 (CK2) is overexpressed in several types of cancer. It has more than 300 substrates mainly involved in DNA reparation and replication, chromatin remodeling and cellular growth. In recent years ...
Estudos das interações do peptídeo antimicrobiano Polybia MP1 com membranas modelo: mecanismo de ação e especificidade
(Universidade Estadual Paulista (UNESP), 2015)
Estudos das interações do peptídeo antimicrobiano Polybia MP1 com membranas modelo: mecanismo de ação e especificidade
(Universidade Estadual Paulista (Unesp), 2015)
Conjugation of Kahalalide F with gold nanoparticles to enhance in vitro antitumoral activity
(2009)
Two Cys-containing analogues of the anticancer drug Kahalalide F are synthesized and conjugated to 20 and 40 nm gold nanoparticles (GNPs). The resulting complexes are characterized by different analytical techniques to ...
Resistance to Degradation and Cellular Distribution Are Important Features for the Antitumor Activity of Gomesin
(Public Library Science, 2013-11-29)
Many reports have shown that antimicrobial peptides exhibit anticancer abilities. Gomesin (Gm) exhibits potent cytotoxic activity against cancer cells by a membrane pore formation induced after well-orchestrated intracellular ...
Estudos biofísicos moleculares e celulares na presença do composto anticâncer (Piperlongumina) utilizando microscopia de força atômica e técnicas espectroscópicas
(Universidade Estadual Paulista (Unesp), 2021-12-16)
Compostos naturais apresentam grande potencial na pesquisa anticâncer, pela inibição do crescimento do tumor, pelas propriedades anti-metastáticas e anti-inflamatórias. A piperlongumina (PL) é um dos compostos naturais que ...
Voltage-Gated K+/Na(+)Channels and Scorpion Venom Toxins in Cancer
(Frontiers Media, 2020)
Ion channels have recently been recognized as novel therapeutic targets in cancer research since they are overexpressed in different histological tissues, and their activity is linked to proliferation, tumor progression, ...