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Properties of mutated murine α4β2 nicotinic receptors linked to partial epilepsy
(Elsevier Ireland, 2008-03)
We characterized, by electrophysiological methods, two biophysical properties of murine recombinant α4β2 nicotinic acetylcholine receptors (nAChR) bearing a mutation (α4:+L264α4:β2 or α4:S252Fα4:β2) linked to autosomal ...
Estudos de modelagem molecular de compostos bioativos frente ao receptor nicotínico de acetilcolina do subtipo alfa4beta2
(Universidade Estadual Paulista (Unesp), 2016)
Neuronal nicotinic acetylcholine receptors (nAChRs) are pentameric transmembrane ion channels located in the central nervous system (CNS) that open and allow the flow of some ions through the action of the endogenous ...
Anesthetics as chemical tools to study the structure and function of nicotinic acetylcholine receptors
(Bentham Science Publishers, 2005-10)
The nicotinic acetylcholine receptor (AChR) is the archetype of the Cys-loop ligand-gated ion channel'receptor superfamily. Noncompetitive antagonists inhibit the AChR without interacting directly with agonist sites. Among ...
Targeting Brain α7 Nicotinic Acetylcholine Receptors in Alzheimer's Disease: Rationale and Current Status.
(Springer, 2014-11)
Alzheimer’s disease (AD) is the most common form of dementia among older persons. Pathognomonic hallmarks of the disease include the development of amyloid senile plaques and deposits of neurofibrillary tangles. These ...
Alpha7 Nicotinic Acetylcholine Receptor Expression and Activity During Neuronal Differentiation of PC12 Pheochromocytoma Cells
(HUMANA PRESS INC, 2010)
Nicotinic acetylcholine receptors (nAChR) exert pivotal roles in synaptic transmission, neuroprotection and differentiation. Particularly, homomeric alpha 7 receptors participate in neurite outgrowth, presynaptic control ...
Cell-surface translational dynamics of nicotinic acetylcholine receptors
(Frontiers Research Foundation, 2014-11)
Synapse efficacy heavily relies on the number of neurotransmitter receptors available at a given time. In addition to the equilibrium between the biosynthetic production, exocytic delivery and recycling of receptors on the ...