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Molecular Dynamics and MM-PBSA Analysis of the SARS-CoV-2 Gamma Variant in Complex with the hACE-2 Receptor
(MDPI, 2022)
The SARS-CoV-2 virus, since its appearance in 2019, has caused millions of cases and deaths. To date, there is no effective treatment or a vaccine that is fully protective. Despite the efforts made by governments and health ...
Eixo ECA2/ANG-(1-7)/mas e sua regulação no processo de ovulação
(Universidade Federal de Santa MariaBRMedicina VeterináriaUFSMPrograma de Pós-Graduação em Medicina Veterinária, 2011-02-28)
The Renin-Angiotensin System (RAS) has been associated with various reproductive
functions, including the ovulatory cascade. Unlike angiotensin II (AngII), the role of
angiotensin-(1-7) [Ang-(1-7)] has not been characterized ...
Polymorphism in gene coding for ACE determines different development of myocardial fibrosis in rats
(AMER PHYSIOLOGICAL SOC, 2004-02-01)
In humans, the effect of angiotensin-converting enzyme (ACE) gene polymorphisms in cardiovascular disease is still controversial. In the rat, a microsatellite marker in the ACE gene allows differentiation of the ACE gene ...
Structural models of human ACE2 variants with SARS-CoV-2 Spike protein for structure-based drug design
Emergence of coronaviruses poses a threat to global health and economy. The current outbreak
of SARS-CoV-2 has infected more than 28,000,000 people and killed more than 915,000. To date,
there is no treatment for coronavirus ...
Renin-angiotensin system blockers and severe acute respiratory syndrome coronavirus 2
Severe acute respiratory syndrome coronavirus 2, which is responsible for the current coronavirus
disease 2019 pandemic, uses angiotensin-converting enzyme 2 as a gateway into host cells. In this
review, we summarize the ...
COVID-19 as a viral functional ACE2 deficiency disorder with ACE2 related multi-organ disease
SARS-CoV-2, the agent of COVID-19, shares a lineage with SARS-CoV-1, and a common fatal pulmonary profile but with striking differences in presentation, clinical
course, and response to treatment. In contrast to SARS-CoV-1 ...
Recent advances in SARS-CoV-2 Spike protein and RBD mutations comparison between new variants Alpha (B.1.1.7, United Kingdom), Beta (B.1.351, South Africa), Gamma (P.1, Brazil) and Delta (B.1.617.2, India)
(2021-09-01)
New variants of SARS-CoV-2 Alpha (B.1.1.7); Beta (B.1.351) Gamma (P.1) and Delta (B.1.617.2) quickly spread in the UK, South Africa, Brazil and India, respectively. To address whether mutations in SARS-CoV-2 RBD spike ...
Overexpression of AT2R in the solitary-vagal complex improves baroreflex in the spontaneously hypertensive rat
(Churchill Livingstone, 2016-12-01)
The aim of this study was to investigate the physiological effects of increased angiotensin II type 2 receptor (AT2R) expression in the solitary-vagal complex (nucleus of the solitary tract/dorsal motor nucleus of the ...