Buscar
Mostrando ítems 51-60 de 233
Progesterone treatment reduces NADPH-diaphorase/Nitric oxide synthase in Wobbler mouse motoneuron disease
(Elsevier Science, 2004-12)
Previous work demonstrated that progesterone (PROG) treatment attenuates morphological, molecular and functional abnormalities in the spinal cord of the Wobbler (Wr) mouse, a genetic model of motoneuron degeneration. Wr ...
Decreased MHC I expression in IFN gamma mutant mice alters synaptic elimination in the spinal cord after peripheral injury
(Biomed Central LtdLondonInglaterra, 2012)
Isl1 is required for multiple aspects of motor neuron development
(Elsevier, 2011-05)
The LIM homeodomain transcription factor Islet1 (Isl1) is expressed in multiple organs and plays essential roles during embryogenesis. Isl1 is required for the survival and specification of spinal cord motor neurons. Due ...
Disulfide cross-linked multimers of TDP-43 and spinal motoneuron loss in a TDP-43(A315T) ALS/FTD mouse model
(Nature Publishing Group, 2017)
Tar DNA binding protein 43 (TDP-43) is the principal component of ubiquitinated protein inclusions present in nervous tissue of most cases of both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). ...
Spinal motoneuron synaptic plasticity after axotomy in the absence of inducible nitric oxide synthase
(Biomed Central LtdLondonInglaterra, 2010)
Astrocytes expressing mutant SOD1 and TDP43 trigger motoneuron death that is mediated via sodium channels and nitroxidative stress
(Frontiers Research Foundation, 2014-02)
Amyotrophic lateral sclerosis (ALS) is a fatal paralytic disorder caused by dysfunction
and degeneration of motor neurons. Multiple disease-causing mutations, including in the
genes for SOD1 and TDP-43, have been identified ...
Neuroprotection by steroids after neurotrauma in organotypic spinal cord cultures: A key role for progesterone receptors and steroidal modulators of GABAA receptors
(Elsevier, 2013-08-31)
Progesterone is neuroprotective after spinal cord injury, however its mechanism of action remains unexplored. Here we used organotypic spinal cord slice cultures from 3 weeks-old mice to evaluate the mechanisms of ...
Motor Recovery and Synaptic Preservation after Ventral Root Avulsion and Repair with a Fibrin Sealant Derived from Snake Venom
(Public Library ScienceSan FranciscoEUA, 2013)