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Doxorubicin Affects Testicular Lipids with Long-Chain (C18-C22) and Very Long-Chain (C24-C32) Polyunsaturated Fatty Acids
(American Association for Cancer Research, 2007-07)
Doxorubicin disrupts spermatogenesis by causing apoptosis of spermatogonia and primary spermatocytes. The aim of this study was to examine the effect of this agent on adult rat testicular lipids and their fatty acids. A ...
Novel evidence for the specific interaction between cholesterol and α-haemolysin of Escherichia coli
(Portland Press, 2014-03)
Several toxins that interact with animal cells present some kind of interaction with cholesterol (Cho) or sphingomyelin. In the present work we demonstrate that alpha hemolysin of E. coli (HlyA) interacts directly with ...
Estudos computacionais de esfingomielinases D: docking, dinâmica molecular e métodos híbridos QM/MM
(Universidade Estadual Paulista (Unesp), 2015-09-29)
Sphingomyelinases D (SMase D) are enzymes that catalyze sphingomyelin in ceramida-1-fosfate and choline. This activity is only found in Loxosceles brown spiders and Corynebacterium pathogenic bacterias. SMase D, or ...
Niemann-Pick Disease: An Approach for Diagnosis in Adulthood
(Palo Alto, CA: Cureus, Inc.Estados Unidos, 2019-05-28)
Niemann-Pick (NP) disease is a rare, autosomal recessive disorder characterized by visceromegaly and neurological alterations due to the excessive storage of lipids, sphingomyelin, and cholesterol. It commonly affects the ...
Structural insights into the catalytic mechanism of sphingomyelinases D and evolutionary relationship to glycerophosphodiester phosphodiesterases
(Elsevier B.V., 2006-03-31)
Spider venom sphingomyelinases D catalyze the hydrolysis of sphingomyelin via an Mg2+ ion-dependent acid-base catalytic mechanism which involves two histidines. In the crystal structure of the sulfate free enzyme determined ...
The lipid composition of a cell membrane modulates the interaction of an antiparasitic peptide at the air-water interface
(Elsevier B.V., 2011-07-01)
The antiparasitic property of peptides is believed to be associated with their interactions with the protozoan membrane, which calls for research on the identification of membrane sites capable of peptide binding. In this ...
Structural insights into the catalytic mechanism of sphingomyelinases D and evolutionary relationship to glycerophosphodiester phosphodiesterases
(Elsevier B.V., 2006-03-31)
Spider venom sphingomyelinases D catalyze the hydrolysis of sphingomyelin via an Mg2+ ion-dependent acid-base catalytic mechanism which involves two histidines. In the crystal structure of the sulfate free enzyme determined ...
Influência da suplementação do ácido graxo ômega 3 na atenuação da cardiotoxicidade induzida pela doxorrubicina em ratos: papel da via da ceramida
(Universidade Estadual Paulista (Unesp), 2021-06-11)
A cardiotoxicidade é o efeito colateral mais grave do tratamento com o quimioterápico doxorrubicina. A identificação dos mecanismos envolvidos na fisiopatologia da cardiotoxicidade permite a descoberta de estratégias de ...
The lipid composition of a cell membrane modulates the interaction of an antiparasitic peptide at the air-water interface
(ELSEVIER SCIENCE BV, 2011)
The antiparasitic property of peptides is believed to be associated with their interactions with the protozoan membrane, which calls for research on the identification of membrane sites capable of peptide binding. In this ...
Combining 25-hydroxycholesterol with an HIV fusion inhibitor peptide: Interaction with biomembrane model systems and human blood cells
(American Chemical Society, 2019-02-28)
The fusion between the viral and the target cell membrane is a crucial step in the life cycle of enveloped viruses. The blocking of this process is a well-known therapeutic approach that led to the development of the fusion ...