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4D-QSAR models applied to the study of TGF- β1 receptor inhibitors
(Bentham Science, 2022)
A concise and efficient synthesis of amino-substituted (1H-benzo[d]imidazol-1-yl)pyrimidine hybrids: Synthetic sequence and the molecular and supramolecular structures of six examples
(2019)
A concise and efficient synthesis of a series of amino-substituted benzimidazole-pyrimidine hybrids has been developed, starting from the readily available N 4-(2-aminophenyl)-6-methoxy-5-nitrosopyrimidine-2,4-diamine. In ...
Emergence of pyridoxal phosphorylation through a promiscuous ancestor during the evolution of hydroxymethyl pyrimidine kinases
(Elsevier, 2014)
In the family of ATP-dependent vitamin kinases, several bifunctional enzymes that phosphorylate
hydroxymethyl pyrimidine (HMP) and pyridoxal (PL) have been described besides enzymes specific
towards HMP. To determine how ...
Synthesis of novel 7-aryl and 7-spiropyrazolo[4 ',3 ':5,6]pyrido [2,3-d]pyrimidine derivatives and their study as AChE inhibitors
(2017)
An efficient route for the synthesis of novel 7-aryl and 7-spiropyrazolo[4', 3':5, 6]pyrido[2,3-d]pyrimidine derivatives is described. These compounds were obtained by a cyclocondensation reaction between pyrazolopyridinediamines ...
Evaluating the pyrimidine metabolism in the plant pathogen Phytophthora infestans as a target to control the late blight disease
(UniandesDoctorado en Ciencias - BiologíaFacultad de CienciasDepartamento de Biología, 2016)
This project studied pyrimidine metabolism in Phytophthora infestans, not only because it has been positioned as a model organism to study oomycetes, it can be grown m vitro and in vivo in potatoes and tomatoes (and some ...
2-amino-3-arildiazenil-pirazolo[1,5-a]pirimidinas trifluormetilsubstituídas: síntese, derivatizações e avaliação das propriedades fotofísicas
(Universidade Federal de Santa MariaBrasilQuímicaUFSMPrograma de Pós-Graduação em QuímicaCentro de Ciências Naturais e Exatas, 2022-08-19)
This thesis presents the results on the synthesis, structural study, and evaluation of the photophysical
properties of new (E)-5-(alkyl/aryl/heteroaryl)-2-amino-3-(aryldiazenyl)-7-(trifluoromethyl)pyrazolo[1,5-
a]pyrimidine ...
Photochemical and electrochemical studies on lanthanide complexes of 6-(hydroxymethyl)pyridine- 2-carboxaldehyde[2- methyl-pyrimidine-4,6-diyl] bis-hydrazone
(Universidad Nacional de Colombia - Sede Bogotá - Facultad de Ciencias - Departamento de Química, 2014-01-01)
Study of the optical and magnetic properties of pyrimidine in water combining PCM and QM/MM methodologies
(ROYAL SOC CHEMISTRY, 2010)
The solvent effects on the low-lying absorption spectrum and on the (15)N chemical shielding of pyrimidine in water are calculated using the combined and sequential Monte Carlo simulation and quantum mechanical calculations. ...
Lapachol, a compound targeting pyrimidine metabolism, ameliorates experimental autoimmune arthritis
(BioMed Central, 2017)
Abstract
Background
The inhibition of pyrimidine biosynthesis by blocking the dihydroorotate dehydrogenase (DHODH) activity, the prime target of leflunomide (LEF), has been ...