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Peptides and peptide-derived molecules targeting the intracellular domains of Cx43: gap junctions versus hemichannels
(Elsevier, 2013)
About a decade ago, the molecular determinants controlling the opening and closing of Cx43 gap junction channels have been identified. Advanced biophysical approaches revealed a critical role for structural rearrangements ...
Inhibition of malaria parasite Plasmodium falciparum development by crotamine, a cell penetrating peptide from the snake venom
(Elsevier Science Inc, 2016)
We show here that crotamine, a polypeptide from the South American rattlesnake venom with cell penetrating and selective anti-fungal and anti-tumoral properties, presents a potent anti-plasmodial activity in culture. ...
Endogenous annexin A1 counter-regulates bleomycin-induced lung fibrosis
(Biomed Central Ltd., 2011-10-19)
Background: The balancing functions of pro/anti-inflammatory mediators of the complex innate responses have been investigated in a variety of experimental inflammatory settings. Annexin-A1 (AnxA1) is one mediator of ...
Recruitment of integrin α ν β 3 to integrin α 5 β 1 -induced clusters enables focal adhesion maturation and cell spreading
(Company of Biologists, 2019-11)
The major fibronectin (FN)-binding α5β1 and αvβ3 integrins exhibit cooperativity during cell adhesion, migration and mechanosensing, through mechanisms that are not yet fully resolved. Exploiting mechanically tunable ...
Peptides and peptide-derived molecules targeting the intracellular domains of Cx43: gap junctions versus hemichannels
(Elsevier, 2013)
About a decade ago, the molecular determinants controlling the opening and closing of Cx43 gap junction channels have been identified. Advanced biophysical approaches revealed a critical role for structural rearrangements ...
OKB, a novel family of brain-gut neuropeptides from insects
(Pergamon-Elsevier Science Ltd, 2012-07)
In insects, neuropeptides play a central role in the control of most physiological processes. The knowledge and characterization of new neuropeptide families, is of interest on the fields of Genetics, Genomics, Neurobiology, ...
Functional proteomics of neuropeptidome dynamics during the feeding process of Rhodnius prolixus
(American Chemical Society, 2011-08)
In hematophagous insects, blood intake triggers a prompt response mediated by neuropeptides, which regulates a variety of physiological processes. Here we report a quantitative proteomic analysis of the postfeeding response ...
Avaliação do papel da proteína anexina A1 e do seu receptor FPR2 em um modelo murino de pneumonia pneumocócica
(Universidade Federal de Minas GeraisUFMG, 2018-02-07)
Pneumococcal pneumonia is the leading cause of community acquired pneumonia and it is responsible for high mortality rates. Pneumonia caused by Streptococcus pneumoniae is characterized by an intense inflammatory response, ...
Endogenous annexin A1 counter-regulates bleomycin-induced lung fibrosis
(Biomed Central Ltd., 2011-10-19)
Background: The balancing functions of pro/anti-inflammatory mediators of the complex innate responses have been investigated in a variety of experimental inflammatory settings. Annexin-A1 (AnxA1) is one mediator of ...
Sintese e avaliação de peptidomiméticos contendo heterociclos de três membros como inibidores de catepsina L
(Universidade Federal de São CarlosUFSCarPrograma de Pós-Graduação em Química - PPGQCâmpus São Carlos, 2017-12-01)
Cathepsin L is a lysosomal cysteine protease, that is related to many physiological processes, however overexpression and up- or downregulation may cause several pathologies. Therefore, cathepsin L became an interesting ...