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Rational design of antiangiogenic helical oligopeptides targeting the vascular endothelial growth factor receptors
(Frontiers Media S.A., 2019-03)
Tumor angiogenesis, essential for cancer development, is regulated mainly by vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs), which are overexpressed in cancer cells. Therefore, the VEGF/VEGFR ...
Thrombospondin-1 (TSP-1) Analogs ABT-510 and ABT- 898 Inhibit Prolactinoma Growth and Recover Active Pituitary Transforming Growth Factor-b1 (TGF-b1)
(Endocrine Society, 2012-06-14)
Prolactinomas are the most prevalent type of secreting pituitary tumors in humans and generally respond well to a medical therapy with dopamine agonists. However, for patients exhibiting resistance to dopaminergic drugs, ...
Cleavage of the NH2-Terminal Octapeptide of Bothrops asper Myotoxic Lysine-49 Phospholipase A2 Reduces Its Membrane-Destabilizing Effect
(1994-08)
Bothrops asper myotoxin II was cleaved with cyanogen bromide to determine the role of NH2-terminal amino acid residues in its ability to destabilize negatively charged liposomes and to induce myonecrosis. After treatment, ...
Adsorption of oligopeptides on silver nanoparticles: surface-enhanced Raman scattering and theoretical studies
(JOHN WILEY & SONS LTD, 2010-01-18)
The MRKDV peptide structurally associated with an immunomodulatory protein, as well as model peptides ADEDRDA and
LGRGISL with common amino acid residues were studied using surface enhanced Raman scattering (SERS) supported ...
Antitumor potential of fibulin-5 in breast cancer cells depends on its RGD cell adhesion motif
(Cell Physiol Biochem Press GmbH & Co KG, 2019)
The Central Nervous System as Target for Antihypertensive Actions of a Proline-Rich Peptide from Bothrops jararaca Venom
(WILEY-LISS, 2010)
Pyroglutamyl proline-rich oligopeptides, present in the venom of the pit viper Bothrops jararaca (Bj-PROs), are the first described naturally occurring inhibitors of the angiotensin I-converting enzyme (ACE). The inhibition ...