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O-GlcNAcylation contributes to the vascular effects of ET-1 via activation of the RhoA/Rho-kinase pathway
(OXFORD UNIV PRESS, 2011)
Aims Glycosylation with beta-N-acetylglucosamine (O-GlcNAcylation) is one of the most complex post-translational modifications. The cycling of O-GlcNAc is controlled by two enzymes: UDP-NAc transferase (OGT) and O-GlcNAcase ...
Spatial-temporal study of Rab1b dynamics and function at the ER-Golgi interface
(Public Library of Science, 2016-08)
The GTPase Rab1b is involved in ER to Golgi transport, with multiple Rab1b effectors (located at ERES, VTCs and the Golgi complex) being required for its function. In this study, we performed live-cell dual-expression ...
Tuba activates cdc42 during neuronal polarization downstream of the small gtpase rab8a
(Society for Neuroscience, 2021-02)
The acquisition of neuronal polarity is a complex molecular process that depends on changes in cytoskeletal dynamics and directed membrane traffic, regulated by the Rho and Rab families of small GTPases, respectively. ...
The Histone Methyltransferase G9a Controls Axon Growth by Targeting the RhoA Signaling Pathway
(Elsevier Science, 2020-05)
The generation of axonal and dendritic domains is critical for brain circuitry assembly and physiology. Negative players, such as the RhoA-Rho coiled-coil-associated protein kinase (ROCK) signaling pathway, restrain axon ...
Decapentaplegic acutely defines the connectivity of central pacemaker neurons in drosophila
(Society for Neuroscience, 2021-08)
Rhythmic rest-activity cycles are controlled by an endogenous clock. In Drosophila, this clock resides in ;150 neurons organized in clusters whose hierarchy changes in response to environmental conditions. The concerted ...
Cdk5 regulates Rap1 activity
(2013)
Rap1 signaling is important for migration, differentiation, axonal growth, and during neuronal polarity. Rap1 can be activated by external stimuli, which in turn regulates specific guanine nucleotide exchange factors such ...
Auto-regulation of Secretory Flux by Sensing and Responding to the Folded Cargo Protein Load in the Endoplasmic Reticulum
(2019-03-07)
Maintaining the optimal performance of cell processes and organelles is the task of auto-regulatory systems. Here we describe an auto-regulatory device that helps to maintain homeostasis of the endoplasmic reticulum (ER) ...
Papel do fator de troca de nucleotídeos guanina RasGEF1b na resposta imune ao protozoário parasito Trypanosoma cruzi
(Universidade Federal de Minas GeraisBrasilICB - INSTITUTO DE CIÊNCIAS BIOLOGICASPrograma de Pós-Graduação em Biologia CelularUFMG, 2018-04-27)
Trypanosoma cruzi, the causative agent of Chagas disease, activates receptors present on cells of innate immunity, such as Toll-like receptors. Intracellular signaling triggered in cells such as macrophages and cardiomyocytes ...