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RNA-binding proteins related to stress response and differentiation in protozoa
(Jingfang Ju, 2016)
Paromomycin: a potential dual targeted drug effectively inhibits both Spike (S1) and Main Protease of COVID-19
Objectives: With increase in number of people suffering from COVID-19, there is a dire need to
look for effective remedies against this pandemic. Drug repurposing seems to be the solution for
current situation.
Methods: ...
Leaving no stone unturned: Allosteric targeting of SARS-CoV-2 Spike protein at putative druggable sites disrupts human angiotensin-converting enzyme interactions at the receptor binding domain.
The systematic entry of SARS-CoV-2 into host cells, as mediated by its Spike (S) protein, is
highly essential for pathogenicity in humans. Hence, targeting the viral entry mechanisms
remains a major strategy for COVID-19 ...
Wrapping Effects within a Proposed Function-Rescue Strategy for the Y220C Oncogenic Mutation of Protein p53
(Public Library Science, 2013-01-24)
Soluble proteins must protect their structural integrity from water attack by wrapping interactions which imply the clustering of nonpolar residues around the backbone hydrogen bonds. Thus, poorly wrapped hydrogen bonds ...
Preparation of N2, N2,7-trimethylguanosine affinity columns
(1999-01-01)
2,2,7-trimethylguanosine (TMG) binding proteins from human cells were purified through TMG-affinity columns. TMG synthesis was improved and the TMG obtained was shown to be similar to the TMG in the 5' cap of the UsnRNAs. ...
Preparation of N2, N2,7-trimethylguanosine affinity columns
(1999-01-01)
2,2,7-trimethylguanosine (TMG) binding proteins from human cells were purified through TMG-affinity columns. TMG synthesis was improved and the TMG obtained was shown to be similar to the TMG in the 5' cap of the UsnRNAs. ...
Cotinine reduces depressive-like behavior and hippocampal vascular endothelial growth factor downregulation after forced swim stress in mice
(American Psychological Association Inc., 2014)
Ultraviolet irradiation of diacetylenic liposomes as a strategy to improve size stability and to alter protein binding without cytotoxicity enhancement
(Taylor & Francis, 2011-06)
Membrane-modification effects, induced by ultraviolet (UV) irradiation in diacetylenic liposomes, were analyzed upon contact with cells, biological membranes, and proteins. Liposomes formulated with mixtures of unsaturated ...