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The highly antigenic 53/25kDa Taenia solium protein fraction with cathepsin-L like activity is present in the oncosphere/cysticercus and induces non-protective IgG antibodies in pigs
(Elsevier, 2012)
Cathepsin L-like proteases are secreted by several parasites including Taenia solium. The mechanism used by T. solium oncospheres to degrade and penetrate the intestine and infect the host is incompletely understood. It ...
New destruxins from the marine-derived fungus Beauveria felina
(2006-09-01)
Chemical investigation of the cytotoxic and anti-tuberculosis active butanone extract obtained from the growth media of the marine-derived fungus Beauveria felina led to the isolation of two new destruxins, [β-MePro] ...
Improving Lurasidone Hydrochloride’s Solubility and Stability by Higher-Order Complex Formation with Hydroxypropyl-β-cyclodextrin
(MDPI, 2023-01)
The biopharmaceutical classification system groups low-solubility drugs into two groups: II and IV, with high and low permeability, respectively. Most of the new drugs developed for common pathologies present solubility ...
Production of fish protein hydrolysates from scyliorhinus canicula discards with antihypertensive & antioxidant activities by enzymatic hydrolysis & mathematical optimization using response surface methodology
(Molecular Diversity Preservation International, 2017-10)
Fish discards are of major concern in new EU policies. Alternatives for the management of the new biomass that has to be landed is compulsory. The production of bioactive compounds from fish protein hydrolysates (FPH) has ...
Drug Metabolism Functionalization (Phase I) Reactions
(Springer Nature Switzerland AG, 2021)
Functionalization (or Phase I) reactions of drug metabolism are those that introduce a functional drug to their substrates (for instance, in hydroxylation) or modify an existing one (e.g., in hydrolysis). The term ...
UHPLC Quantitation Method and In vitro Studies of Two New Phthalimide Derivatives Planned to Treat Sickle Cell Disease
(Bentham Science Publ Ltd, 2017-01-01)
Background: Sickle cell disease is characterized by the occurrence of acute disability and progressive organ damage, and it is one of the most common and severe monogenic disorders around the world. Since hydroxycarbamide ...
Monoclonal antibodies carried in drug delivery nanosystems as a strategy for cancer treatment
(2021-01-01)
Monoclonal antibodies carried in nanosystems have been extensively studied and reported as a promising tool for the treatment of various types of cancers. Monoclonal antibodies have great advantages for the treatment of ...
Development of an analytical method for the quantification of pfaffic acid in Brazilian ginseng (Hebanthe eriantha)
(2013-04-05)
Hebanthe eriantha (Poir.) Pedersen (Amaranthaceae), which is known as Brazilian ginseng is widely used in folk medicine as an aphrodisiac and antidiabetic tonic. The anti-tumor activity, attributed to the pfaffic acid ...
Polybitoxins: A group of phospholipases A2 from the venom of the neotropical social wasp paulistinha (Polybia paulista)
(1998-01-01)
The neotropical wasp Polybia paulista is very aggressive and endemic in south-east Brazil, where it frequently causes stinging accidents. By using gel filtration on Sephadex G-200, followed by ion-exchange chromatography ...