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Impact of the processes of total testicular regression and recrudescence on the epididymal physiology of the bat myotis nigricans (chiroptera: vespertilionidae)
(Public Library Science, 2015-06-09)
Myotis nigricans is a species of vespertilionid bat, whose males show two periods of total testicular regression within the same annual reproductive cycle in the northwest Sao Paulo State, Brazil. Studies have demonstrated ...
Low-dose in utero exposure to finasteride promotes developmental changes in both male and female gerbil prostates
(2019-01-01)
The prostate is an accessory reproductive gland that is sensitive to the action of exogenous compounds known as endocrine disrupters that alter normal hormonal function. Finasteride is a widely used chemical that acts to ...
Postnatal exposure to finasteride causes different effects on the prostate of male and female gerbils
(2020-06-01)
The development and maintenance of prostate function depend on a fine balance between oestrogen and androgen levels. Finasteride inhibits 5α-reductase, which is responsible for the conversion of testosterone into its most ...
Ovarian sex steroid receptors and sex hormones in androgenized rats
(2016-01-01)
This study evaluated for the first time the effects of different doses of the anabolic steroid nandrolone decanoate (ND) on the expression of ovarian steroid receptors (AR, ER-α (ESR1) and ER-β (ESR2)) and related sex ...
Limits of Visual Detection for Finasteride Polymorphs in Prepared Binary Mixtures: Analysis by X-ray Powder Diffraction
(Wiley-Blackwell, 2014-11-01)
Finasteride (FNT) is a drug that inhibits human enzyme type II 5-reductase that metabolizes testosterone into dihydrotestosterone. There are two enantiotropic polymorphs with known crystal structure: designated as forms I ...
Neonatal exposure to single doses of estradiol or testosterone programs ovarian follicular development-modified hypothalamic neurotransmitters and causes polycystic ovary during adulthood in the rat
(2011)
Objective: To investigate the hormones participating in early follicular development and hypothalamic neurotransmitters in rats during adulthood. Design: Experimental basic study. Setting: University animal laboratory. ...
Modulation of androgen receptor protein by culture conditions of human skin fibroblasts
(2002)
Cultures of skin fibroblasts show variation of androgen binding with culture conditions; binding variations are usually avoided by using confluent cultures. In this work, we analysed the effect of cell density and mitogenic ...
Administração de toxina botulínica A e a orquiectomia no tratamento da hiperplasia prostática benigna do cão
(2015-01-01)
The pathogenesis of benign prostatic hyperplasia (BPH) is not completely known, however, dihydrotestosterone is a hormone involved in enlargement of the prostate. Recently, the effect of botulinum toxin A (BT-A) was ...
5α-reductase type 3 enzyme in benign and malignant prostate
(2014-02)
BACKGROUND Currently available 5α-reductase inhibitors are not completely effective for treatment of benign prostate enlargement, prevention of prostate cancer (CaP), or treatment of advanced castration-recurrent (CR) CaP. ...
Activational Action Of Testosterone On Androgen Receptors Protects Males Preventing Temporomandibular Joint Pain
(Pergamon-Elsevier Science LTDOxford, 2017)