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Carbon Monoxide Modulates Connexin Function through a Lipid Peroxidation-Dependent Process: A Hypothesis.
(Lausanne : Frontiers Research Foundation, 2016)
Hemichannels are ion channels composed of six connexins (Cxs), and they have the peculiarity to be permeable not only to ions, but also to molecules such as ATP and glutamate. Under physiological conditions they present a ...
Connexin and Pannexin hemichannels are regulated by redox potential
(Frontiers Research Foundation, 2014)
Connexins (Cxs) and Pannexins (Panxs) are two non-related protein families, having both
the property to form hemichannels at the plasma membrane. There are 21 genes coding
for different Cx based proteins and only 3 for ...
Role of ROS/RNS in Preeclampsia: Are Connexins the Missing Piece?
(2020)
Preeclampsia is a pregnancy complication that appears after 20 weeks of gestation and is characterized by hypertension and proteinuria, affecting both mother and offspring. The cellular and molecular mechanisms that cause ...
Role of Akt and Ca2+ on cell permeabilization via connexin43 hemichannels induced by metabolic inhibition
(Elsevier, 2015)
© 2015 Elsevier B.V. Connexin hemichannels are regulated under physiological and pathological conditions. Metabolic inhibition, a model of ischemia, promotes surface hemichannel activation associated, in part, with increased ...
Connexin 43 hemichannels and pannexin-1 channels contribute to the α-synuclein-induced dysfunction and death of astrocytes
(John Wiley and Sons Inc., 2019)
Gap junctions and communication within the nervous system
(Botucatu, 2008)
Gap junctions are sites on the cellular membrane with intercellular channels build up by twelve protein subunits called connexins. Each connected cell contributes with a hemichannel made up by six connexins subunits. This ...
New insights on the role of connexins and Gap Junctions Channels in adipose tissue and Obesity
(MDPI, 2021)
Due to the inability to curb the excessive increase in the prevalence of obesity and overweight, it is necessary to comprehend in more detail the factors involved in the pathophysiology and to appreciate more clearly the ...