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REDUCTION OF beta-AMYLOID-INDUCED NEUROTOXICITY ON HIPPOCAMPAL CELL CULTURES BY MODERATE ACIDOSIS IS MEDIATED BY TRANSFORMING GROWTH FACTOR beta
(PERGAMON-ELSEVIER SCIENCE LTD, 2009)
Progression of Alzheimer's disease (AD) is associated with chronic inflammation and microvascular alterations, which can induce impairment of brain perfusion because of vascular pathology and local acidosis. Acidosis can ...
APOE and Alzheimer’s Disease: Evidence Mounts that Targeting APOE4 may Combat Alzheimer’s Pathogenesis
(Humana Press Inc., 2019)
Alzheimer´s amyloid beta interacts with cellular prion protein inducing neuronal membrane damage and synaptotoxicity.
(2015)
A major feature of Alzheimer's disease is the accumulation of beta-amyloid (A beta) peptide in the brain. Recent studies have indicated that A beta oligomers (A beta o) can interact with the cellular prion protein (PrPc). ...
Degradation of soluble amyloid beta-peptides 1-40, 1-42, and the Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brains.
(Springer/Plenum Publishers, 2000-12)
Insulin degrading enzyme (IDE) is a metalloprotease that has been involved in amyloid beta peptide (A(beta)) degradation in the brain. We analyzed the ability of human brain soluble fraction to degrade A(beta) analogs 1-40, ...
Aβ-Amyloid fibrils are self-triggered by the interfacial lipid environment and low peptide content
(American Chemical Society, 2020-07-21)
We studied the surface properties of Aβ(1-40) amyloid peptides mixed with 1-palmitoyl-2-oleoyl-phosphatidylcholine (POPC) (liquid state) or 1,2-disteraoyl-phosphatidylcholine (DSPC) (solid state) phospholipids by using ...
β-amyloid inhibits protein prenylation and induces cholesterol sequestration by impairing SREBP-2 cleavage
(Society for Neuroscience, 2012-05-09)
Accumulation of β-amyloid (Aβ) inside brain neurons is an early and crucial event in Alzheimer's disease (AD). Studies in brains of AD patients and mice models of AD suggested that cholesterol homeostasis is altered in ...
alpha and beta Conformational preferences in fibril forming peptides characterised using NMR and CD techniques
(Ios PressAmsterdamHolanda, 2004)
Modulating amyloid fibrillation in a minimalist model peptide by intermolecular disulfide chemical reduction
(Royal Society of Chemistry, 2019-05)
Peptide structural transformation and aggregation is associated with a large number of outsider aetiology diseases, and it is intrinsically linked to amyloid peptide aggregation. Diphenylalanine self-assembled structures ...