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Cascade ligand- and structure-based virtual screening to identify new trypanocidal compounds inhibiting putrescine uptake
(Frontiers Media SA, 2018-05)
Chagas disease is a neglected tropical disease endemic to Latin America, though migratory movements have recently spread it to other regions. Here, we have applied a cascade virtual screening campaign combining ligand- and ...
De las pizarras a las pantallas, un reto docente en EcuadorFrom blackboards to screens, a teaching challenge in Ecuador
(Universidad Nacional de Educación, 2021)
De las pizarras a las pantallas, un reto docente en EcuadorFrom blackboards to screens, a teaching challenge in Ecuador
(Universidad Nacional de Educación, 2021)
Pharmacophore Model of Cruzain Inhibitors
(WILEY-V C H VERLAG GMBH, 2009)
Chagas disease, caused by the protozoan Trypanosoma cruzi, is one of the most serious amongst the so-called neglected diseases in Latin America, specially in Brazil. So far there has been no effective treatment for the ...
Crystal structure of Schistosoma purine nucleoside phosphorylase complexed with a novel monocyclic inhibitor
(ELSEVIER SCIENCE BV, 2010)
A novel inhibitor of Schistosoma PNP was identified using an ""in silico"" approach allied to enzyme inhibition assays. The compound has a monocyclic structure which has not been previously described for PNP inhibitors The ...
In silico identification of noncompetitive inhibitors targeting an uncharacterized allosteric site of falcipain-2
(2021-01-01)
Falcipain-2 (FP-2) is a Plasmodium falciparum hemoglobinase widely targeted in the search for antimalarials. FP-2 can be allosterically modulated by various noncompetitive inhibitors that have been serendipitously identified. ...
Virtual screening of new targets and inhibitors for Candida albicans infection control
(Cartagena de IndiasCampus Tecnológico, 2021-10-13)
Infection by Candida albicans fungus is considered of biomedical interest, producing significant mortality and comorbidity. The development of pathogen resistance during pharmacological treatments is increasing, thus, the ...
Mosis LAB: uma solução interativa em realidade virtual imersiva
(Universidade do Vale do Rio dos Sinos, 2020-08-20)
The technological evolution of the last few years has brought a series of advances to the area of computing. Computers became smaller and with greater processing power, screens had their resolutions increased and became ...
Mosis LAB: uma solução interativa em realidade virtual imersiva
(Universidade do Vale do Rio dos Sinos, 2020-08-20)
The technological evolution of the last few years has brought a series of advances to the area of computing. Computers became smaller and with greater processing power, screens had their resolutions increased and became ...