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Bioactive compound profiling of olive fruit: the contribution of genotype
(MDPI, 2022-04)
The health, therapeutic, and organoleptic characteristics of olive oil depend on functional bioactive compounds, such as phenols, tocopherols, squalene, and sterols. Genotype plays a key role in the diversity and concentration ...
Synthesis, characterization and antifungal assessment of optically active bis-organotin compounds derived from (S)-BINOL diesters
(Bentham Science Publishers, 2019-05)
Background: Organotin(IV) derivatives have appeared recently as potential biologically active metallopharmaceuticals exhibiting a variety of therapeutic activities. Hence, it is important to study the synthesis of new ...
Deposição de DNA no fígado como um novo fenômeno da lesão hepática medicamentosa
(Universidade Federal de Minas GeraisBrasilICB - INSTITUTO DE CIÊNCIAS BIOLOGICASPrograma de Pós-Graduação em Biologia CelularUFMG, 2014-08-01)
Drug-induced liver injury (DILI) is an important cause of acute liver failure (FHA), but with limited therapeutic options. During DILI, oncotic necrosis with concomitant release and recognition of intracellular content ...
Estudo sobre o potencial antitumoral de derivados esterificados do ácido cumárico
(Universidade Federal de São Paulo, 2022)
O câncer ainda representa um dos maiores desafios da medicina moderna, sendo que as terapias disponíveis envolvem diversos efeitos colaterais e nem sempre são acessíveis à população em geral. Nesse sentido, o estudo ...
Search of vasopressin analogs with antiproliferative activity on small-cell lung cancer: Drug design based on two different approaches
(Future Medicine, 2018-04)
Aim: Development of compounds with therapeutic application requires the interaction of different disciplines. Several tumors express vasopressin (AVP; arginine vasopressin) receptors with contrasting effects depending on ...
Efecto de derivados de ácido benzoico sobre la expresión del gen trans-sialidasa en epimastigotes de Trypanosoma cruzi
(2018-04-09)
RESUMEN: Actualmente, la enfermedad de Chagas causada por el parásito Trypanosoma cruzi (T.
cruzi) es un problema epidemiológico, económico y social que afecta de 6 a 7 millones de
personas en América Latina. Solo existen ...