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FoxO3a nuclear localization and its association with beta-catenin and Smads in IFN-alfa-treated hepatocellular carcinoma cell lines
(Mary Ann Liebert Inc, 2014-11)
Interferon-a2b (IFN-a2b) reduces proliferation and increases apoptosis in hepatocellular carcinoma cells by decreasing b-catenin/TCF4/Smads interaction. Forkhead box O-class 3a (FoxO3a) participates in proliferation and ...
Estudo da via de sinalização do nodal no endométrio e na fisiopatologia da endometriose
(Universidade Federal de Minas GeraisUFMG, 2013-09-13)
In the present study we investigated the role of Nodal, member of the TGF-beta family, and proteins related to their mechanism of signal transduction in endometrial stromal cells stimulated or not with Estrogen (10 nM), ...
Trastuzumab inhibits pituitary tumor cell growth modulating the TGFB/SMAD2/3 pathway
(BioScientifica, 2018-10)
In pituitary adenomas, early recurrences and resistance to conventional pharmacotherapies are common, but the mechanisms involved are still not understood. The high expression of epidermal growth factor receptor 2 ...
The role of chromosomal instability in cancer and therapeutic responses
(2018)
Cancer is one of the leading causes of death, and despite increased research in recent years, control of advanced-stage disease and optimal therapeutic responses remain elusive. Recent technological improvements have ...