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α-Adrenoceptor and opioid receptor modulation of clonidine-induced antinociception
(John Wiley and Sons Inc., 1996)
1. The antinociceptive action of clonidine (Clon) and the interactions with α1, α2 adrenoceptor and opioid receptor antagonists was evaluated in mice by use of chemical algesiometric test (acetic acid writhing test). 2. ...
Mu and kappa opioid receptors of the periaqueductal gray stimulate and inhibit thermogenesis, respectively, during psychological stress in rats
(Springer, 2017-09-01)
The periaqueductal gray matter (PAG) is rich in mu and kappa opioid receptors, and this system is involved in thermoregulation, analgesia, and defensive behaviors. No study approached the involvement of the PAG opioids in ...
Papel dos receptores kappa opioides e sua interação com receptores 5-HT1A no teste da estimulação elétrica na substância cinzenta periaquedutal dorsal de ratosRole of kappa opioid receptors and their interaction with 5-HT1A receptors in the electrical stimulation test in the dorsal periaqueductal gray of rats
(Universidade Estadual de MaringáBrasilDepartamento de Farmacologia e TerapêuticaPrograma de Pós-Graduação em Ciências FarmacêuticasUEMMaringá, PRCentro de Ciências da Saúde, 2018)
Peripheral sensitization increases opioid receptor expression and activation by Crotalphine in rats
(Public Library of ScienceSan Francisco, 2014-03-04)
Inflammation enhances the peripheral analgesic efficacy of opioid drugs, but the mechanisms involved in this phenomenon have not been fully elucidated. Crotalphine (CRP), a peptide that was first isolated from South American ...
Cross-tolerance to acute administration of mu and kappa opioid agonists at the spinal cord level in the rat
(1996)
Development of tolerance and cross-tolerance after acute administration of the μ agonist morphine and the K agonist U-50,488H was assessed in rats, through recording of a C-fiber-evoked spinal nociceptive reflex. Rats ...
Do opioid receptors play a role in the pathogenesis of the inflammatory response in acute pancreatitis?
(ACTA CIRURGICA BRASILEIRASÃO PAULO, 2012-09)
PURPOSE: To investigate the effect of the opioid blocker naltrexone in the inflammatory response in acute pancreatitis (AP). METHODS: Acute pancreatitis was induced in anesthetized male Wistar rats by retrograde injection ...
Altered nucleus accumbens circuitry mediates pain-induced antinociception in morphine-tolerant rats
(Soc NeuroscienceWashingtonEUA, 2002)
κ Opioid receptor-mediated depression of activity evoked in convergent dorsal horn cells by thermal and non-thermal noxious stimulation
(1990)
The response of convergent dorsal horn cells to tonic and phasic noxiuos heating and to noxious pinching was studied and after topical application of a solution (30 nmol) of the κ agonist U-50,488H to the dorsal surface ...