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Estudo dos mecanismos moleculares da via de sinalização à resposta a danos ao DNA relacionada com o reparo acoplado à transcrição em Trypanosoma cruzi.
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIAPrograma de Pós-Graduação em Bioquímica e ImunologiaUFMG, 2021-11-03)
Transcriptional stress which leads to RNA polymerase arrest can be caused by damage to the DNA. The stalled RNA polymerase is a significant signal to begin the transcription-coupled repair (TC-NER). Our previous results ...
Investigação do possível efeito quimiopreventivo do suco de uva concentrado nos focos de criptas aberrantes (FCA’S) no cólon induzido pelo azoximetano (AOM) em ratos Wistar
(Universidade Federal de São Paulo (UNIFESP), 2013-03-27)
Introdução: A uva é uma fruta rica em fenólicos que tem múltiplos efeitos biológicos, tais como atividade antioxidante, anti-inflamatória
antimicrobiana e anticarcinogênica. Objetivo: Avaliar se o suco de uva administrado ...
Mammalian Staufen 1 is recruited to stress granules and impairs their assembly
(Company of Biologists, 2009-02)
Stress granules are cytoplasmic mRNA-silencing foci that form transiently during the stress response. Stress granules harbor abortive translation initiation complexes and are in dynamic equilibrium with translating polysomes. ...
SALL2 represses cyclins D1 and E1 expression and restrains G1/S cell cycle transition and cancer-related phenotypes
(2018)
SALL2 is a poorly characterized transcription factor that belongs to the Spalt-like family involved in development. Mutations on SALL2 have been associated with ocular coloboma and cancer. In cancers, SALL2 is deregulated ...
Drosophila ataxin-2 gene encodes two differentially expressed isoforms and its function in larval fat body is crucial for development of peripheral tissues
(2016-11-01)
Different isoforms of ataxin-2 are predicted in Drosophila and may underlie different cellular processes. Here, we validated the isoforms B and C of Drosophila ataxin-2 locus (dAtx2), which we found to be expressed in ...
SALL2 represses cyclins D1 and E1 expression and restrains G1/S cell cycle transition and cancer-related phenotypes
(Wiley, 2018-06)
SALL2 is a poorly characterized transcription factor that belongs to the Spalt-like family involved in development. Mutations on SALL2 have been associated with ocular coloboma and cancer. In cancers, SALL2 is deregulated ...
Estudio biofísico del mecanismo de acción del receptor de glucocorticoidesBiophysical study of the glucocorticoid receptor mechanism of action
(2018-03-27)
El núcleo celular es una organela con una organización espacial muy compleja. Los componentes responsables de las distintas funciones nucleares, como la replicación y la reparación del ADN, la transcripción y el procesamiento ...