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Rab GTPase signaling in neurite outgrowth and axon specification
(John Wiley and Sons Inc., 2016)
© 2016 Wiley Periodicals, Inc. Neurons are highly polarized cells that contain specialized subcellular domains involved in information transmission in the nervous system. Specifically, the somatodendritic compartment ...
Rab1b Interacts with GBF1 and Modulates both ARF1 Dynamics and COPI Association
(American Society for Cell Biology, 2007-07)
Assembly of the cytosolic coat protein I (COPI) complex at the ER-Golgi interface is directed by the ADP ribosylation factor1 (Arf1) and its guanine nucleotide exchange factor (GBF1). Rab1b GTPase modulates COPI recruitment, ...
Rab-mediated trafficking role in neurite formation
(International Society for Neurochemistry, 2014)
Neuronal cells are characterized by the presence of two
confined domains, which are different in their cellular properties,
biochemical functions and molecular identity. The generation
of asymmetric domains in neurons ...
Rab3A, a possible marker of cortical granules, participates in cortical granule exocytosis in mouse eggs
(Elsevier Inc, 2016-09)
Fusion of cortical granules with the oocyte plasma membrane is the most significant event to prevent polyspermy. This particular exocytosis, also known as cortical reaction, is regulated by calcium and its molecular mechanism ...
Rab5 is required in metastatic cancer cells for caveolin-1-enhanced Rac1 activation, migration and invasion
(Company of Biologists Ltd, 2014)
Rab5 is a small GTPase that regulates early endosome trafficking and other cellular processes, including cell adhesion and migration. Specifically, Rab5 promotes Rac1 activation and cancer cell migration, but little is ...
Androgen deprivation from pre-puberty to peripuberty interferes in proteins expression in pubertal and adult rat epididymis
(2013-07-01)
Few studies have focused on experimental testosterone deprivation in immature animals. Therefore, this study used sexually immature rats aiming to evaluate the testes and epididymis histology and proteins expression in ...
Androgen deprivation from pre-puberty to peripuberty interferes in proteins expression in pubertal and adult rat epididymis
(2013-07-01)
Few studies have focused on experimental testosterone deprivation in immature animals. Therefore, this study used sexually immature rats aiming to evaluate the testes and epididymis histology and proteins expression in ...
Use of a synthetic lethal screen to identify genes related to TIF51A in Saccharomyces cerevisiae
(2007-05-18)
The putative eukaryotic translation initiation factor 5A (eIF5A) is an essential protein for cell viability and the only cellular protein known to contain the unusual amino acid residue hypusine. eIF5A has been implicated ...
Use of a synthetic lethal screen to identify genes related to TIF51A in Saccharomyces cerevisiae
(2007-05-18)
The putative eukaryotic translation initiation factor 5A (eIF5A) is an essential protein for cell viability and the only cellular protein known to contain the unusual amino acid residue hypusine. eIF5A has been implicated ...
Epac, Rap and Rab3 act in concert to mobilize calcium from sperm's acrosome during exocytosis
(BioMed Central, 2014-08)
BACKGROUND: Exocytosis of sperm's single secretory granule or acrosome (acrosome reaction, AR) is a highly regulated event essential for fertilization. The AR begins with an influx of calcium from the extracellular milieu ...