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On the mechanisms of phenothiazine-induced mitochondrial permeability transition: Thiol oxidation, strict Ca2+ dependence, and cyt c release
(Elsevier B.V., 2010-10-15)
Phenothiazines (PTZ) are drugs widely used in the treatment of schizophrenia. Trifluoperazine, a piperazinic PTZ derivative, has been described as inhibitor of the mitochondrial permeability transition (MPT). We reported ...
Plasma homocysteine and thiol redox states in HIV+patients
(2014-01-01)
Human immunodeficiency virus (HIV) replication induces oxidative stress that is produced by the constituent proteins of the virus and is amplified by host-cell immunological defenses. In general, the disease progresses ...
Oxidative damage to sarcoplasmic reticulum Ca2+-pump induced by Fe2+/H2O2/ascorbate is not mediated by lipid peroxidation or thiol oxidation and leads to protein fragmentation
(Kluwer Academic PublDordrechtHolanda, 1996)
Toxic effects of apomorphine on rat cultured neurons and glial C6 cells, and protection with antioxidants
(Biochemical Pharmacology, 2001-01-01)
Many catechol derivatives are currently used as drugs, even if they produce reactive oxygen species that may cause tissue damage. Among them, apomorphine, a potent dopamine agonist, displays efficient anti-parkinsonian ...
Mechanism of cysteine oxidation by peroxynitrite: an integrated experimental and theoretical study
(Elsevier, 2013-08)
Since peroxynitrite was identified as a pathophysiological agent it has been implicated in a great variety of cellular processes. Particularly, peroxynitrite mediated oxidation of cellular thiol-containing compounds such ...
Efeito do Harpagophytum procumbens sobre parâmetros de estresse oxidativo e a viabilidade celular in vitro
(Universidade Federal de Santa MariaBRFarmacologiaUFSMPrograma de Pós-Graduação em Farmacologia, 2013-10-04)
Harpagophytum procumbens, known as devil's claw, is an African plant with numerous therapeutic effects, among which stands out for its powerful anti-inflammatory action, but the mechanism by which exerts its effect is not ...
Mitochondrial permeability transition induced by chemically generated singlet oxygen
(Kluwer Academic/plenum PublNew YorkEUA, 2002)
Inhibition of cytosolic glutathione S-transferase activity from rat liver by copper
(ELSEVIER, 2006-12-01)
H2O2 inactivation of particular GST isoforms has been reported, with no information regarding the overall effect of other ROS on cytosolic GST activity. The present work describes the inactivation of total cytosolic GST ...