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Polymorphism at 129 dictates metastable conformations of the human prion protein N-terminal β-sheet
(Royal Society of Chemistry, 2017-08-30)
We study the thermodynamic stability of the native state of the human prion protein using a new free-energy method, replica-exchange on-the-fly parameterization. This method is designed to overcome hidden-variable sampling ...
Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis
(2008)
The unfolded protein response (UPR) is a conserved adaptive reaction that increases cell survival under endoplasmic reticulum (ER) stress conditions. X-box-binding protein-1 (XBP-1) is a key transcriptional regulator of ...
Prion pathogenesis is independent of caspase-12
(Taylor and Francis Inc., 2007)
© 2007 Landes Bioscience. The pathogenic mechanism(s) underlying neurodegenerative diseases associated with protein misfolding is unclear. Several studies have implicated ER stress pathways in neurodegenerative conditions, ...
Prionic diseasesDoenças priônicas
(Academia Brasileira de Neurologia, 2019)
Reduction of prion infectivity in packed red blood cells
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2008-12-12)
The link between a new variant form of Creutzfeldt-Jakob disease (vCJD) and the consumption of prion contaminated cattle meat as well as recent findings showing that vCJD can be transmitted by blood transfusion have raised ...
Molecular Cross Talk between Misfolded Proteins in Animal Models of Alzheimer’s and Prion Diseases
(2010-03-31)
The central event in protein misfolding disorders (PMDs) is the accumulation of a misfolded form of a naturally expressed protein.
Despite the diversity of clinical symptoms associated with different PMDs, many similarities ...
Estudios de complejos de cobre (II) para modelación del sitio activo de la proteína Prión
(Universidad Nacional de Ingeniería, 2013)