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Epigenetic control of cell cycle-dependent histone gene expression is a principal component of the abbreviated pluripotent cell cycle.
(2012)
Self-renewal of human pluripotent embryonic stem cells proceeds via an abbreviated cell cycle with a shortened G1 phase. We examined which genes are modulated in this abbreviated period and the epigenetic mechanisms that ...
Epigenetic control of cell cycle-dependent histone gene expression is a principal component of the abbreviated pluripotent cell cycle.
(2012)
Self-renewal of human pluripotent embryonic stem cells proceeds via an abbreviated cell cycle with a shortened G(1) phase. We examined which genes are modulated in this abbreviated period and the epigenetic mechanisms that ...
A deficitary model of CDK5 does not impairs neuronal differentiation of human pluripotent stem cells
(Medicina, 2021)
CDK5/P35 is a complex involved in neuronal homeostasis and de- velopment that was described as a critical player for neuronal surviv- al. Besides, its deregulation is linked with neurodegenerative pathol- ogies such as ...
Pluripotent nontumorigenic adipose tissue-derived muse cells have immunomodulatory capacity mediated by transforming growthfactor-β1
(Wiley Blackwell Publishing, Inc, 2017-01)
Adult mesenchymal stromal cell-based interventions have shown promising results in a broad range of diseases. However, their use has faced limited effectiveness owing to the low survival rates and susceptibility to ...
A therapy-grade protocol for differentiation of pluripotent stem cells into mesenchymal stem cells using platelet lysate as supplement
(BioMed Central Ltd., 2015-01)
Introduction: Mesenchymal stem cells (MSCs) are a promising source of cells for regenerative therapies. Although they can be isolated easily from several tissues, cell expansion is limited since their properties are lost ...
Myosin VI Reduces Proliferation, but Not Differentiation, in Pluripotent P19 Cells
(Public Library of Science, 2013-05-17)
Background:We have previously shown marked upregulation of the mRNA and corresponding protein for the cellular motor molecule myosin VI (Myo6) after an extremely traumatic stress experience, along with a delayed decrease ...
Altered iPSC-derived neurons' sodium channel properties in subjects with Monge's disease
(Elsevier, 2015)
Monge’s disease, also known as chronic mountain sickness (CMS), is a disease that potentially threatens more than 140 million highlanders during extended time living at high altitudes (over 2500 m). The prevalence of CMS ...
Forced Expression of Nanog in Human Bone Marrow-Derived Endothelial Cells Activates Other Six Pluripotent Genes
(MARY ANN LIEBERT INCNEW ROCHELLE, 2012)
Human endothelial cells (ECs) have the ability to make up the lining of blood vessels. These cells are also capable of neovascularization and revascularization and have been applied in various clinical situations. With the ...