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Sildenafil (Viagra®) prevents and restores LPS-induced inflammation in astrocytes
(2016-09-06)
Astrocytes are effectively involved in the pathophysiological processes in the central nervous system (CNS) and may contribute to or protect against development of inflammatory and degenerative diseases. Sildenafil is a ...
Control of oocyte maturation
(2014-01-01)
Oocyte maturation is a complex process involving nuclear and cytoplasmic maturation. The nuclear maturation is a chromosomal segregation and the cytoplasmic maturation involves the reorganization of the cytoplasmic organelles, ...
Control of oocyte maturation
(Brazilian Coll Animal Reproduction, 2014-07-01)
Oocyte maturation is a complex process involving nuclear and cytoplasmic maturation. The nuclear maturation is a chromosomal segregation and the cytoplasmic maturation involves the reorganization of the cytoplasmic organelles, ...
Decreased activity of the Na+/H+ exchanger by phosphodiesterase 5A inhibition is attributed to an increase in protein phosphatase activity
(Lippincott Williams, 2010-10)
The beneficial effect of phosphodiesterase 5A inhibition in ischemia/reperfusion injury and cardiac hypertrophy is well established. Inhibition of the cardiac Na(+)/H(+) exchanger (NHE-1) exerts beneficial effects on ...
Comparison of in vivo and in vitro properties of cyclic adenosine 3':5' monophosphate phosphodiesterase of amphibian oocytes
(1977)
The cAMP levels of single Xenopus laevis oocytes are shown to range from 1 to 4 μM and those of isolated nuclei to be about 7 to 10 μM. The oocyte is capable of hydrolyzing a large molar excess of microinjected cAMP, rapidly ...
Tryptophan and aspartic acid residues present in the glycerophosphoryl diester phosphodiesterase (GDPD) domain of the Loxosceles laeta phospholipase D are essential for substrate recognition
(PERGAMON-ELSEVIER SCIENCE LTD, 2014)
It is known that the family of phospholipases D (PLD) from spiders of the genus Loxosceles, hydrolyze the substrates sphingomyelin and lisophosphatidylcholine, by their catalytic acid-base action which involves two histidines. ...
Phosphodiesterase inhibitor pentoxifylline: An antiinflammatory/immunomodulatory drug potentially useful in some rheumatic diseases
Phosphodiesterase inhibitor pentoxifylline: an antiinflammatory/immunomodulatory drug potentially useful in some rheumatic diseases: Adjuvants, Immunologic/therapeutic use, Animals, Anti-Inflammatory Agents, Non-Steroida ...