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Insights into peptide-membrane interactions of newly synthesized, nitroxide-containing analogs of the peptaibiotic trichogin GA IV using EPR
(John Wiley & Sons Inc, 2017-01)
Trichogin GA IV is a short-length (10-amino acid long), mostly hydrophobic, peptaibiotic with an N-terminal fatty acyl chain and a C-terminal 1,2-amino alcohol. A cardinal role of the terminal moieties in the cytotoxic ...
Computer-assisted assessment of potentially useful non-peptide HIV-1 protease inhibitors
(Elsevier Science BvAmsterdamHolanda, 2012)
Peptides of the liver stage antigen-1 (LSA-1) of Plasmodium falciparum bind to human hepatocytes
Synthetic peptides from the liver stage antigen-1 (LSA-1) antigen sequence were used in HepG2 cell and erythrocyte binding assays to identify regiones thar could be involuved in parasite invesion. LSA-1 protein peptides ...
Peptide-lipid interaction monitored by spin labeled biologically active melanocortin peptides
(Elsevier B.V., 2005-10-01)
The present work comparatively analyzes the interaction of alpha-MSH and its more potent and long-acting analog [Nle(4), D-Phe(7)]alpha-MSH (NDP-MSH) with lipid bilayers. the peptides were spin labeled with Toac ...
Insertion of an electronegative sulfur atom in the side chain of position 5 of angiotensin II: changes in the tachyphylactic properties of the peptide
(Munksgaard Int Publ Ltd, 1999-06-01)
Angiotensin II (All) analogs bearing n-Leu, Met or S-substituted groups for cysteine at position 5 were studied regarding their agonistic and tachyphylactic properties. It was shown that these analogs lowered the relative ...
N-terminal acetylation of a mastoparan-like peptide enhances PE/PG segregation in model membranes
(2020-10-01)
The synthetic peptides L1A and its acetylated analog (acL1A) display potent Gram-negative bactericidal activities without being hemolytic. We have gathered evidence that the N-terminal acetylation of L1A enhances the lytic ...
Antiplasmodial activity study of angiotensin II via Ala scan analogs
(Wiley-Blackwell, 2014-08-01)
Angiotensin II (AII) as well as analog peptides shows antimalarial activity against Plasmodium gallinaceum and Plasmodium falciparum, but the exact mechanism of action is still unknown. This work presents the solid-phase ...
Effects of Dimerization on the Structure and Biological Activity of Antimicrobial Peptide Ctx-Ha
(Amer Soc Microbiology, 2014)
Reduction of tumor angiogenesis induced by desmopressin in a breast cancer model
(Springer, 2013-10)
Desmopressin (DDAVP), a synthetic peptide analog of vasopressin, is a safe antidiuretic and hemostatic compound that acts as a selective agonist for the vasopressin V2 membrane receptor. It is known that DDAVP can inhibit ...