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Open-label phase 3 study of intravenous golimumab in patients with polyarticular juvenile idiopathic arthritis
(Oxford University Press, 2021)
Objectives: To assess efficacy, pharmacokinetics (PK) and safety of intravenous (i.v.) golimumab in patients with polyarticular-course JIA (pc-JIA). Methods: Children aged 2 to <18 years with active pc-JIA despite MTX ...
Minimally important difference estimates and methods: a protocol
(BMJ Publishing Group, 2015)
Introduction Patient-reported outcomes (PROs) are often the outcomes of greatest importance to patients. The minimally important difference (MID) provides a measure of the smallest change in the PRO that patients perceive ...
Imatinib after induction for treatment of children and adolescents with Philadelphia-chromosome-positive acute lymphoblastic leukaemia (EsPhALL): A randomised, open-label, intergroup study
(2012)
Background
Trials of imatinib have provided evidence of activity in adults with Philadelphia-chromosome-positive acute lymphoblastic leukaemia (ALL), but the drug's role when given with multidrug chemotherapy to children ...
Clinical features of childhood granulomatosis with polyangiitis (wegener's granulomatosis)
(Biomed Central Ltd, 2014-05-26)
Background: Granulomatosis with polyangiitis (GPA), formerly known as Wegener's granulomatosis (WG), belongs to the group of ANCA-associated necrotizing vasculitides. This study describes the clinical picture of the disease ...
Chronic autoimmune urticaria as the first manifestation of juvenile systemic lupus erythematosus
(SAGE PUBLICATIONS LTD, 2011)
Chronic urticaria (daily or almost daily symptoms lasting for more than six weeks) is characterized by wheals and erythema, with or without itching. A few case reports have shown chronic autoimmune urticaria at the beginning ...
Nova classificação das vasculites pediátricas
(2011)
Vasculitis is an umbrella term for blood-vessel wall inflammation involving large, medium and small vessels, in different organs and systems. It encompasses several diseases with heterogeneous clinical features and similar ...