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Characterization of a neutralizing anti-human galectin-1 monoclonal antibody with angioregulatory and immunomodulatory activities
(Springer, 2021-10)
Galectins, a family of highly conserved β-galactoside-binding proteins, control tumor progression by modulating different hallmarks of cancer. Galectin-1 (Gal-1), a proto-type member of this family, plays essential roles ...
Rabies VLPs adjuvanted with saponin-based liposomes induce enhanced immunogenicity mediated by neutralizing antibodies in cattle, dogs and cats
(Elsevier Science, 2020-12)
We carried out an investigation on rabies virus-like particles (RV-VLPs) expressed in HEK293 cells using serum free medium. These RV-VLPs were formulated with two different adjuvants in order to analyse the enhancement of ...
A scFv antibody fragment as a therapeutic candidate to neutralize a broad diversity of human IFN-alpha subtypes
(Elsevier Science, 2008-05)
Despite their significant role in maintaining the normal physiology, cytokines may cause pathological conditions when they are overproduced. In this way, the increased expression of human interferon alpha (hIFN-α) is ...
Functional and in silico Characterization of Neutralizing Interactions Between Antibodies and the Foot-and-Mouth Disease Virus Immunodominant Antigenic Site
(Frontiers Media, 2021-05)
Molecular knowledge of virus–antibody interactions is essential for the development of better vaccines and for a timely assessment of the spread and severity of epidemics. For foot-and-mouth disease virus (FMDV) research, ...
Use of adjuvant ISA VG 71 to produce neutralizing egg yolk antibodies against bothropic venom
(Springer, 2023-02)
The use of egg yolk antibodies—IgY technology—represents an alternative to the production of mammalian immunoglobulins and has several advantages regarding animal welfare and lower costs of production. The use of adjuvants ...
In vivo neutralization of bee venom lethality by IgY antibodies
(Elsevier, 2021-07)
Bee venom is a complex mixture of molecules, among which melittin and phospholipase A2 (PLA2) are the toxic components involved in envenoming accidents with multiple honeybee stings. Traditionally, the treatment of envenomings ...
Production of monoclonal antibodies for Avian Metapneumovirus (SHS-BR-121) isolated in Brazil
(Fundação APINCO de Ciência e Tecnologia Avícolas, 2007)