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The negative inotropic action of canrenone is mediated by L-type calcium current blockade and reduced intracellular calcium transients
(Wiley-Blackwell, 2009-09-01)
Background and purpose:Adding spironolactone to standard therapy in heart failure reduces morbidity and mortality, but the underlying mechanisms are not fully understood. We analysed the effect of canrenone, the major ...
Verapamil-sensitive Ca2+ channel regulation of Th1-type proliferation of splenic lymphocytes induced by Walker 256 tumor development in rats
(Elsevier Science BvAmsterdamHolanda, 2006)
Amyotrophic lateral sclerosis-immunoglobulins selectively interact with neuromuscular junctions expressing P/Q-type calcium channels
(Wiley Blackwell Publishing, Inc, 2011-11)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by a gradual loss of motoneurons. The majority of ALS cases are associated with a sporadic form whose etiology is unknown. Several ...
Gamma band activity in the reticular activating system
(Frontiers Head Office-Online publication, 2012-01)
This review considers recent evidence showing that cells in three regions of the reticular activating system (RAS) exhibit gamma band activity, and describes the mechanisms behind such manifestation. Specifically, we discuss ...
The Drosophila ortholog of the schizophrenia-associated CACNA1A and CACNA1B voltage-gated calcium channels regulate memory, sleep and circadian rhythms
(Academic Press Inc., 2021)
© 2021 The AuthorsSchizophrenia exhibits up to 80% heritability. A number of genome wide association studies (GWAS) have repeatedly shown common variants in voltage-gated calcium (Cav) channel genes CACNA1C, CACNA1I and ...
Mechanisms for consideration for intervention in the development of organophosphorus-induced delayed neuropathy
(Elsevier B.V., 2012-09-30)
Organophosphorus-induced delayed neuropathy (OPIDN) is a neurodegenerative disorder characterised by ataxia progressing to paralysis with concomitant central and peripheral distal axonopathy. Symptoms of OPIDN in people ...
Mechanisms for consideration for intervention in the development of organophosphorus-induced delayed neuropathy
(Elsevier B.V., 2012-09-30)
Organophosphorus-induced delayed neuropathy (OPIDN) is a neurodegenerative disorder characterised by ataxia progressing to paralysis with concomitant central and peripheral distal axonopathy. Symptoms of OPIDN in people ...
Calcium Transport and Local Pool Regulate Polycystin-2 (TRPP2) Function in Human Syncytiotrophoblast
(Cell Press, 2013-07-16)
Polycystin-2 (PC2, TRPP2) is a Ca2+ -permeable, nonselective cation channel implicated in Ca2+ transport and epithelial cell signaling. Although PC2 may contribute to Ca2+ transport in human term placenta, the regulatory ...