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Reduced major histocompatibility complex class II polymorphism in a hunter-managed isolated Iberian red deer population
(Wiley Blackwell Publishing, Inc, 2009-02)
The major histocompatibility complex (MHC) contains the most variable functionalgenes described in vertebrates. Individuals from natural populations dealconstantly with a diverse range of pathogens and the polymorphism at ...
Immunohistochemical characterization of mononuclear cells and MHC II expression in the brain of horses with experimental chronic Trypanosoma evansi infection
(Colégio Brasileiro de Parasitologia Veterinária, 2014)
Brucella abortus down-regulates MHC class II by the IL-6-dependent inhibition of CIITA through the downmodulation of IFN regulatory factor-1 (IRF-1)
(Society for Leukocyte Biology, 2016-10)
Brucella abortus is an intracellular pathogen capable of surviving inside of macrophages. The success of B. abortus as a chronic pathogen relies on its ability to orchestrate different strategies to evade the adaptive CD4+ ...
Tumor venéreo transmissível canino - I. Expressão gênica e proteica e caracterização genotípica de DLADQA-1 (MHC-II); II. Estudo imuno-histoquímico da resposta imune local
(Universidade Estadual Paulista (Unesp), 2015-11-20)
The canine transmissible venereal tumor (CTVT) is a transmissible cancer that is spread between dogs by the allogeneic transfer of living cancer cells during coitus. It is the oldest cancer lineage known in nature and one ...
Bioinformatics tools for the prediction of T-cell epitopes
(Springer, 2018-05)
T-cell responses are activated by specific peptides, called epitopes, presented on the cell surface by MHC molecules. Binding of peptides to the MHC is the most selective step in T-cell antigen presentation and therefore ...
MiRNA-208a and miRNA-208b are triggered in thyroid hormone-induced cardiac hypertrophy - role of type 1 Angiotensin II receptor (AT1R) on miRNA-208a/α-MHC modulation
(North Holland PublishingLimerick, 2013-06-15)
Hyperthyroidism promotes cardiac hypertrophy and the Angiotensin type 1 receptor (AT1R) has been demonstrated to mediate part of this response. Recent studies have uncovered a potentially important role for the microRNAs ...
Unconventional peptide presentation by major histocompatibility complex (MHC) class i allele HLA-A∗02:01: Breaking confinement
(American Society for Biochemistry and Molecular Biology, 2017-03)
Peptide antigen presentation by major histocompatibility complex (MHC) class I proteins initiates CD8+ T cell-mediated immunity against pathogens and cancers.MHCI molecules typically bind peptides with 9 amino acids in ...
Retinal pigment epithelial cells are heterogeneous in their expression of MHC-II after stimulation with interferon-gamma
(Academic Press Ltd, 1999-04-01)
The pattern of interferon-gamma-induced major histocompatibility complex Class II antigen expression was evaluated on the retinal pigment epithelium. Experiments were performed in vitro using explant cultures of aged and ...
Selecao genetica bidirecional de linhagens de cobaias boas e mas produtoras de anticorpos contra eritrocitos heterologos
(Universidade Federal de São Paulo (UNIFESP), 1979)