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Tyrosine hydroxylase deficiency: a treatable disorder of brain catecholamine biosynthesis
(OXFORD UNIV PRESS, 2010)
Tyrosine hydroxylase deficiency is an autosomal recessive disorder resulting from cerebral catecholamine deficiency. Tyrosine hydroxylase deficiency has been reported in fewer than 40 patients worldwide. To recapitulate ...
Biochemical characterization of a protein tyrosine phosphatase from Trypanosoma cruzi involved in metacyclogenesis and cell invasion
(Elsevier B.V., 2011-05-13)
Protein tyrosine phosphatases (PTPs) form a large family of enzymes involved in the regulation of numerous cellular functions in eukaryotes. Several protein tyrosine phosphatases have been recently identified in trypanosomatides. ...
Osteoblastic protein tyrosine phosphatases inhibition and connexin 43 phosphorylation by alendronate
(Elsevier, 2014-05)
Bisphosphonates (BPs), potent inhibitors of bone resorption which inhibit osteoclasts, have also been shown to act on osteocytes and osteoblasts preventing apoptosis via connexin (Cx) 43 hemichannels and activating the ...
Angiotensin-(1-7) through AT2 receptors mediates tyrosine hydroxylase degradation via the ubiquitin-proteasome pathway
(Wiley Blackwell Publishing, Inc, 2009-01)
Hypothalamic norepinephrine (NE) release regulates arterial pressure by altering sympathetic nervous system activity. Because angiotensin (Ang) (1-7) decreases hypothalamic NE release and this effect may be correlated with ...
Epithelial cells treated with genistein inhibit adhesion and endocytosis of Paracoccidioides brasiliensis
(Springer, 2007-07-01)
Paracoccidioidomycosis is caused by Paracoccidioides brasiliensis, which although not formally considered an intracellular pathogen, can be internalized by epithelial cells in vitro and in vivo. The mechanisms used by P. ...