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Molecular profiling to identify relevant immune resistance mechanisms in the tumor microenvironment
(Elsevier, 2011-04)
The molecular identification of tumor antigens initially catalyzed substantial enthusiasm for the development of tumor antigen-based vaccines for the treatment of cancer. However, numerous vaccine approaches in ...
Direct effect of Plasmodium vivax recombinant vaccine candidates AMA-1 and MSP-1(19) on the innate immune response
(ELSEVIER SCI LTD, 2008)
The recombinant apical membrane antigen 1 (AMA-1) and 19-kDa fragment of merozoite surface protein (MSP-1(19)) are the lead candidates for inclusion in a vaccine against blood stages of malaria due to encouraging protective ...
Role played by the programmed death-1-programmed death ligand pathway during innate immunity against Mycobacterium tuberculosis
(University of Chicago Press, 2010-08)
Tuberculous pleurisy allows the study of specific cells at the site of Mycobacterium tuberculosis infection. Among pleural lymphocytes, natural killer (NK) cells are a major source of interferon γ (IFN-γ), and their functions ...
5-Lipoxygenase Deficiency Impairs Innate and Adaptive Immune Responses during Fungal Infection
(Public Library Science, 2012-03-20)
5-lipoxygenase-derived products have been implicated in both the inhibition and promotion of chronic infection. Here, we sought to investigate the roles of endogenous 5-lipoxygenase products and exogenous leukotrienes ...
5-Lipoxygenase Deficiency Impairs Innate and Adaptive Immune Responses during Fungal Infection
(Public Library Science, 2012-03-20)
5-lipoxygenase-derived products have been implicated in both the inhibition and promotion of chronic infection. Here, we sought to investigate the roles of endogenous 5-lipoxygenase products and exogenous leukotrienes ...
Immune responses induced by inactivated vaccine against Aeromonas hydrophila in pacu, Piaractus mesopotamicus
(2020-06-01)
Aeromonas hydrophila is responsible for outbreaks of a severe infectious disease in fish farms around the world and is one of the major causes of economic losses to the neotropical fish farmers. This study assessed the ...
Genetic background and thermal environment differentially influence the ontogeny of immune components during early life in an ectothermic vertebrate
(Wiley Blackwell Publishing, Inc, 2020-05)
1.An understudied aspect of vertebrate ecoimmunology has been the relative contributions of environmental factors (E), genetic background (G) and their interaction (G × E) in shaping immune development and function. ...
Modulation of host immunity by human respiratory syncytial virus virulence factors: a synergic inhibition of both innate and adaptive immunity
(2017)
The Human Respiratory Syncytial Virus (hRSV) is a major cause of acute lower respiratory tract infections (ARTIs) and high rates of hospitalizations in children and in the elderly worldwide. Symptoms of hRSV infection ...
Innate immune sensing of cancer: clues from an identified role for type I IFNs
(Springer, 2012-06)
A subset of patients with a variety of cancers shows evidence of a natural adaptive immune response against their tumor, as evidenced by spontaneous T-cell infiltration, circulating anti-tumor T cells, or antibody responses. ...