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Development of PEG-PCL-based polymersomes through design of experiments for co-encapsulation of vemurafenib and doxorubicin as chemotherapeutic drugs
(2022-03-01)
Nanostructures for co-encapsulation of chemotherapeutic drugs have been widely studied for the last years due to its important advantages, e.g. improved bioavailability and cellular uptake, increased solubility of drugs, ...
Nanodrug Delivery Systems for Dermal and Transdermal Photosensitizer Drugs
(2017-03-29)
Skin is the largest organ in the human body and functions as a protective barrier. Molecules can penetrate the skin by three main routes: (1) intracellular (across the corneocytes), (2) intercellular lipids, and (3) ...
In silico modeling of FDA-approved drugs for discovery of therapies against neglected diseases: A drug repurposing approach
(Elsevier, 2019)
Drug repurposing (i.e., finding new therapeutic uses for already known drugs, including approved, abandoned, discontinued, and investigational drugs) is being extensively applied worldwide to expedite the development of ...
Shikimate kinase: A potential target for development of novel antitubercular agents
(Bentham Science Publ Ltd, 2014)
Approaches for the development of drugs for treatment of obesity and metabolic syndrome
(Bentham Science Publishers, 2016)
Planejamento de fármacos, biotecnologia e química medicinal: Aplicações em doenças infecciosas
(2010-12-21)
Current drug design strategies are based on the understanding of the physiopathology of diseases, biochemical pathways and selection of molecular targets. Modern biotechnological tools have provided valuable information ...
Yeast Double Transporter Gene Deletion Library for Identification of Xenobiotic Carriers in Low or High Throughput
(Amer Soc Microbiology, 2021-11-01)
The routes of uptake and efflux should be considered when developing new drugs so that they can effectively address their intracellular targets. As a general rule, drugs appear to enter cells via protein carriers that ...
Chorismate synthase: An attractive target for drug development against orphan diseases
(2007-03-01)
The increase in incidence of infectious diseases worldwide, particularly in developing countries, is worrying. Each year, 14 million people are killed by infectious diseases, mainly HIV/AIDS, respiratory infections, malaria ...