Buscar
Mostrando ítems 51-60 de 91
Obtenção de micro/nanopartículas poliméricas para o encapsulamento do fármaco bromidrato de galantamina
(Universidade Estadual Paulista (UNESP), 2014)
Estudos computacionais e sintéticos visando o planejamento racional de novos agentes anticolinesterásicos
(Universidade Estadual Paulista (UNESP), 2014)
Efeito do tratamento do extrato padronizado de Ginkgo Biloba (EGb) na memória de esquiva discriminativa, em ratos de meia idade submetidos ao modelo de alzheimer pela administração intracerebroventricular de estreptozotocina.
(Universidade Federal de São Paulo, 2022-12-19)
A doença de Alzheimer (DA) é uma doença com origem multifatorial, dentre os
faotres destacamos a resistência à insulina encefálica, o que resultou na origem do termo
diabetes encefálica ou diabetes tipo 3. A DA tem sido ...
Síntese e reatividade de N-alquinilindóis: preparação de N-alquinilindóis-2-substituídos e calcogenazolo[3,2-a]indóis
(Universidade Federal de Santa MariaBrasilQuímicaUFSMPrograma de Pós-Graduação em QuímicaCentro de Ciências Naturais e Exatas, 2020-02-21)
This work reports the preparation of 2-Substituted-N-alkynylindoles 3 (18 examples) with yields that varied from 30 to 90%, via the metalation reaction of N-alkynylindoles 1 followed by the capture of 2-indolyl lithium ...
Synthesis and biological evaluation of potential acetylcholinesterase inhibitors based on a benzoxazine core
(Wiley-VCH Verlag, 2018)
© 2018 Deutsche Pharmazeutische Gesellschaft With the purpose of expanding the structural variety of chemical compounds available as pharmacological tools for the treatment of Alzheimer's disease, we synthesized and evaluated ...
Pharmacotherapies for Parkinson’s disease symptoms related to cholinergic degeneration
(Informa Healthcare, 2016-10)
Introduction: Dopamine depletion is one of the most important features of Parkinson’s Disease (PD). However, insufficient response to dopaminergic replacement therapy suggests the involvement of other neurotransmitter ...
Targeting Brain α7 Nicotinic Acetylcholine Receptors in Alzheimer's Disease: Rationale and Current Status.
(Springer, 2014-11)
Alzheimer’s disease (AD) is the most common form of dementia among older persons. Pathognomonic hallmarks of the disease include the development of amyloid senile plaques and deposits of neurofibrillary tangles. These ...
Design, facile synthesis, and evaluation of novel spiro- and pyrazolo [1,5-c]quinazolines as cholinesterase inhibitors: Molecular docking and MM/GBSA studies
(2018)
Given the wide spectrum of biological uses of pyrazolo[l,5-c]quinazoline and spiro-quinazoline derivatives as anticancer, anti-inflammatory analgesic agents, and their therapeutic applications in neurodegenerative disorders, ...
Targeting Brain alpha;7 Nicotinic Acetylcholine Receptors in Alzheimer's Disease: Rationale and Current Status.
(Adis Int Ltd, 2014-11)
Alzheimer´s disease (AD) is the most common form of dementia among older persons. Pathognomonic hallmarks of the disease include the development of amyloid senile plaques and deposits of neurofibrillary tangles. These ...