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Impact of exercise training on redox signaling in cardiovascular diseases
(Pergamon PressOxford, 2013-12)
Reactive oxygen and nitrogen species regulate a wide array of signaling pathways that governs cardiovascular physiology. However, oxidant stress resulting from disrupted redox signaling has an adverse impact on the ...
Development and initial validation of a composite disease activity score for systemic juvenile idiopathic arthritis
(2020-11-01)
Objective. To develop a composite disease activity score for systemic JIA (sJIA) and to provide preliminary evidence of its validity. Methods. The systemic Juvenile Arthritis Disease Activity Score (sJADAS) was constructed ...
Natural and synthetic naphthoquinones active against Trypanosoma cruzi: An initial step towards new drugs for chagas disease
(2011)
Chagas disease is one of the most important endemic diseases in Latin America, caused by Trypanosoma cruzi. The drugs used for the treatment of this disease, nifurtimox and benznidazole, are toxic and present severe side ...
Preliminary Studies on Temperature Selection and Activity Cycles of Triatoma infestans and T. spinolai (Heteroptera: Reduviidae), Chilean Vectors of Chagas' Disease
(Entomological Society of America, 1997)
Preferred temperature and activity patterns of Triatoma infestans Klug and Triatoma spinolai Porter were studied, both are vectors of Chagas' disease in Chile. In the laboratory, 24 T. spinolai and 18 T. infestans were ...
Remission and low disease activity state (LDAS) are protective of intermediate and long-term outcomes in SLE patients. Results from LUMINA (LXXVIII), a multiethnic, multicenter US cohort
(SAGE Publications, 2019)
Objective: The objective of this report is to determine the impact of remission and low disease activity state (LDAS) on damage accrual and mortality in systemic lupus erythematosus (SLE) patients. Patients and methods: ...
Special Issue: Activity and Lifestyle Factors in the Elderly: Their Relationship with Degenerative Diseases and Depression
(AIMS PRESS, 2016-06)
Much has been written over the ages about the benefits of exercise and physical activity. Marcus Tullius Cicero stated, in _65 BC, that ?It is exercise alone that supports the spirits, and keeps the mind in vigor?. Over ...
Brain Na+, K+-ATPase activity In aging and disease
(Master Publishing Group, 2014-07)
Na+/K+ pump or sodium- and potassium-activated adenosine 5’-triphosphatase (Na+, K+-ATPase), its enzymatic version, is a crucial protein responsible for the electrochemical gradient across the cell membranes. It is an ion ...
Prodrugs for the treatment of neglected diseases
(Molecular Diversity Preservation Int, 2008-03-01)
Recently, World Health Organization ( WHO) and Medicins San Frontieres (MSF) proposed a classification of diseases as global, neglected and extremely neglected. Global diseases, such as cancer, cardiovascular and mental ...
Cardiovascular remodeling induced by passive smoking
(2009-12-01)
Coronary heart disease (CHD) is the most common cause of death in many developed countries. The major risk factors for CHD are smoking, high blood pressure, diabetes, high cholesterol levels, and lack of physical activity. ...
Soluble ST2: A new and promising activity marker in ulcerative colitis
(BAISHIDENG PUBL GRP CO LTD, 2011)
AIM: To correlate circulating soluble ST2 (sST2) levels with the severity of ulcerative colitis (UC) and serum levels of pro-inflammatory cytokines, and to demonstrate the predictive power of sST2 levels for differentiation ...