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Signal Sensing and Transduction by Histidine Kinases as Unveiled through Studies on a Temperature Sensor
(American Chemical Society, 2017-06)
Histidine kinases (HK) are the sensory proteins of two-component systems, responsible for a large fraction of bacterial responses to stimuli and environmental changes. Prototypical HKs are membrane-bound proteins that ...
Nuclear localization of MUC1 extracellular domain in breast, head and neck, and colon cancer
(SAGE Publications, 2015-06)
Background: The glycoprotein MUC1 is overexpressed and underglycosylated in cancer cells. MUC1 is translated as a single polypeptide that undergoes autocleavage into 2 subunits (the extracellular domain and the cytoplasmic ...
Cap binding-independent recruitment of eIF4E to cytoplasmic foci
(Elsevier Science, 2012)
A lipid-mediated conformational switch modulates the thermosensing activity of DesK
(National Academy Of Sciences, 2014-02)
The thermosensor DesK is a multipass transmembrane histidine-kinase that allows the bacterium Bacillus subtilis to adjust the levels of unsaturated fatty acids required to optimize membrane lipid fluidity. The cytoplasmic ...
Crystallization and initial X-ray diffraction analysis of the multi-domain Brucella blue light-activated histidine kinase LOV-HK in its illuminated state
(Elsevier, 2018-12)
The pathogenic bacterium Brucella abortus codes for a multi-domain dimeric cytoplasmic histidine kinase called LOV-HK, which is a key blue light-activated virulence factor in this microorganism. The structural basis of the ...
Targeting of mRNAs within the glial cell cytoplasm: how to hide the message along the journey
(Wiley-liss, Div John Wiley & Sons Inc, 2000-11)
The subcellular targeting of mRNAs encoding myelin proteins to the oligodendrocyte processes is an accepted fact in myelin formation. How these messengers are kept silent during their movement to the subcellular domain ...
Central role of the oxygen-dependent degradation domain of Drosophila HIFα/Sima in oxygen-dependent nuclear export.
(American Society for Cell Biology, 2009-07)
The Drosophila HIFalpha homologue, Sima, is localized mainly in the cytoplasm in normoxia and accumulates in the nucleus upon hypoxic exposure. We have characterized the mechanism governing Sima oxygen-dependent subcellular ...
Distinct functional domains of the Salmonella enterica WbaP transferase that is involved in the initiation reaction for synthesis of the O antigen subunit
(2008)
WbaP is a membrane enzyme that initiates O antigen synthesis in Salmonella enterica by catalysing the transfer of galactose 1-phosphate (Gal-1-P) onto undecaprenyl phosphate (Und-P). WbaP possesses at least three predicted ...
The role of superoxide anion in the inhibitory effect of SIN-1 in thrombin-activated human platelet adhesion
(Elsevier Science BvAmsterdamHolanda, 2010)
The shape of the transmembrane domain is a novel endocytosis signal for single-spanning membrane proteins
(Company of Biologists, 2017-11-15)
Endocytosis is crucial for all cells as it allows them to incorporate material from the extracellular space and control the availability of transmembrane proteins at the plasma membrane. In yeast, endocytosis followed by ...